Humans
Showing 69631 to 69640 of 95995 articles
Pharmacokinetic and safety profile of tofacitinib in children with polyarticular course juvenile idiopathic arthritis: results of a phase 1, open-label, multicenter study.
Pediatric rheumatology online journal
Dec 28, 2017
BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and a leading cause of childhood disability. The objective of this study was to characterize the PK, safety, and taste acceptability of tofacitinib in pati...
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Overexpression of EMMPRIN is associated with lymph node metastasis and advanced stage of non-small cell lung cancer: a retrospective study.
BMC pulmonary medicine
Dec 28, 2017
BACKGROUND: Previous studies show that overexpression of EMMPRIN involved in the malignant biological behavior of tumors. This investigation was to disclose the expression status of EMMPRIN in non-small cell lung cancer (NSCLC) and its clinical value...
Deep convolutional neural networks for pan-specific peptide-MHC class I binding prediction.
BMC bioinformatics
Dec 28, 2017
BACKGROUND: Computational scanning of peptide candidates that bind to a specific major histocompatibility complex (MHC) can speed up the peptide-based vaccine development process and therefore various methods are being actively developed. Recently, m...
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Pseudoneglect in Visual Search: Behavioral Evidence and Connectional Constraints in Simulated Neural Circuitry.
eNeuro
Dec 28, 2017
Most people tend to bisect horizontal lines slightly to the left of their true center (pseudoneglect) and start visual search from left-sided items. This physiological leftward spatial bias may depend on hemispheric asymmetries in the organization of...
Framework for Infectious Disease Analysis: A comprehensive and integrative multi-modeling approach to disease prediction and management.
Health informatics journal
Dec 27, 2017
The impact of infectious disease on human populations is a function of many factors including environmental conditions, vector dynamics, transmission mechanics, social and cultural behaviors, and public policy. A comprehensive framework for disease m...
Investigation of genotoxic effects of paraben in cultured human lymphocytes.
Drug and chemical toxicology
Dec 27, 2017
Paraben is a phenolic derivative of benzoic acid extensively used as preservatives in food, pharmaceutical, and cosmetic industries due to its antimicrobial characteristics. The objective of this study was to evaluate the in vitro genotoxic effects o...
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The same analysis approach: Practical protection against the pitfalls of novel neuroimaging analysis methods.
NeuroImage
Dec 27, 2017
Standard neuroimaging data analysis based on traditional principles of experimental design, modelling, and statistical inference is increasingly complemented by novel analysis methods, driven e.g. by machine learning methods. While these novel approa...
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Convective radiofrequency water vapor thermal therapy for benign prostatic hyperplasia: a single office experience.
Prostate cancer and prostatic diseases
Dec 27, 2017
BACKGROUND: Convective radiofrequency water vapor thermal therapy with the Rezūm system is a relatively new treatment for benign prostatic hyperplasia (BPH). We present results from a single surgeon in an office setting.
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Serum Cardiac Troponin T Levels in Asymptomatic Elderly Nursing Home Residents.
The American journal of medicine
Dec 27, 2017
BACKGROUND: The definition of myocardial infarction relies on elevated troponin levels. However, elevated levels of high sensitive cardiac troponin (hs-cTnT) assays have been reported in elderly patients without acute myocardial infarction. We sought...
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