AIMC Topic: Immunosuppressive Agents

Clear Filters Showing 11 to 20 of 49 articles

Improved Arterial Stiffness Indices 3 and 6 Months after Living-donor Renal Transplantation.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia Mar 11, 2024
Arterial stiffness is a non-traditional risk factor of cardiovascular disease and may explain part of the excess cardiovascular risk in chronic kidney disease patients. Successful renal transplantation (RT) may restore renal function and improve seve...
Time Factors Treatment Outcome Young Adult Age Factors Kidney Failure, Chronic Immunosuppressive Agents Adult Pulse Wave Analysis Humans Male Vascular Stiffness Calcineurin Inhibitors Middle Aged Living Donors Kidney Transplantation Prospective Studies Female
View on PubMed DOI

Algorithmic Identification of Treatment-Emergent Adverse Events From Clinical Notes Using Large Language Models: A Pilot Study in Inflammatory Bowel Disease.

Clinical pharmacology and therapeutics Mar 8, 2024
Outpatient clinical notes are a rich source of information regarding drug safety. However, data in these notes are currently underutilized for pharmacovigilance due to methodological limitations in text mining. Large language models (LLMs) like Bidir...
Humans Algorithms Inflammatory Bowel Diseases Electronic Health Records Female Natural Language Processing Drug-Related Side Effects and Adverse Reactions Data Mining Pharmacovigilance Adverse Drug Reaction Reporting Systems Hospitalization Male Pilot Projects Immunosuppressive Agents
View on PubMed DOI

An Unbiased Machine Learning Exploration Reveals Gene Sets Predictive of Allograft Tolerance After Kidney Transplantation.

Frontiers in immunology Jul 8, 2021
Efforts at finding potential biomarkers of tolerance after kidney transplantation have been hindered by limited sample size, as well as the complicated mechanisms underlying tolerance and the potential risk of rejection after immunosuppressant withdr...
Treatment Outcome Databases, Genetic Immunosuppressive Agents Predictive Value of Tests Oligonucleotide Array Sequence Analysis Transplantation Tolerance Graft Rejection Patient Selection Gene Expression Profiling Transcriptome Time Factors Kidney Transplantation Graft Survival Humans Clinical Decision-Making Machine Learning Risk Factors Risk Assessment
View on PubMed DOI

Mycophenolic Acid Exposure Prediction Using Machine Learning.

Clinical pharmacology and therapeutics Apr 6, 2021
Therapeutic drug monitoring of mycophenolic acid (MPA) based on area under the curve (AUC) is well-established and machine learning (ML) approaches could help to estimate AUC. The aim of this work is to estimate the AUC of MPA in organ transplant pat...
Bayes Theorem Organ Transplantation Models, Biological Mycophenolic Acid Adult Dose-Response Relationship, Drug Humans Male Immunosuppressive Agents Machine Learning Middle Aged Time Factors Female Area Under Curve Comorbidity Age Factors Aged
View on PubMed DOI

Estimation of drug exposure by machine learning based on simulations from published pharmacokinetic models: The example of tacrolimus.

Pharmacological research Mar 26, 2021
We previously demonstrated that Machine learning (ML) algorithms can accurately estimate drug area under the curve (AUC) of tacrolimus or mycophenolate mofetil (MMF) based on limited information, as well as or even better than maximum a posteriori Ba...
Humans Machine Learning Adult Immunosuppressive Agents Area Under Curve Tacrolimus Models, Biological Monte Carlo Method
View on PubMed DOI

Application Prospect of Artificial Intelligence in Rehabilitation and Management of Myasthenia Gravis.

BioMed research international Mar 4, 2021
Myasthenia gravis (MG) is a chronic autoimmune disease of the nervous system, which is still incurable. In recent years, with the progress of immunosuppressive and supportive treatment, the therapeutic effect of MG in the acute stage is satisfactory,...
Artificial Intelligence Clinical Decision-Making Immunosuppressive Agents Myasthenia Gravis Humans
View on PubMed DOI

Tacrolimus Exposure Prediction Using Machine Learning.

Clinical pharmacology and therapeutics Jan 18, 2021
The aim of this work is to estimate the area-under the blood concentration curve of tacrolimus (TAC) following b.i.d. or q.d. dosing in organ transplant patients, using Xgboost machine learning (ML) models. A total of 4,997 and 1,452 TAC interdose ar...
Humans Machine Learning Immunosuppressive Agents Area Under Curve Drug Administration Schedule Bayes Theorem Organ Transplantation Tacrolimus Models, Biological
View on PubMed DOI

Machine learning predicts stem cell transplant response in severe scleroderma.

Annals of the rheumatic diseases Sep 15, 2020
OBJECTIVE: The Scleroderma: Cyclophosphamide or Transplantation (SCOT) trial demonstrated clinical benefit of haematopoietic stem cell transplant (HSCT) compared with cyclophosphamide (CYC). We mapped PBC (peripheral blood cell) samples from the SCOT...
Gene Expression Profiling Transcriptome Machine Learning Scleroderma, Diffuse Hematopoietic Stem Cell Transplantation Adult Treatment Outcome Humans Female Cyclophosphamide Male Immunosuppressive Agents Middle Aged
View on PubMed DOI

Patterns of 1,748 Unique Human Alloimmune Responses Seen by Simple Machine Learning Algorithms.

Frontiers in immunology Jul 28, 2020
Allele specific antibody response against the polymorphic system of HLA is the allogeneic response marker determining the immunological risk for graft acceptance before and after organ transplantation and therefore routinely studied during the patien...
Treatment Outcome Cluster Analysis Immunosuppressive Agents Principal Component Analysis HLA Antigens Pattern Recognition, Automated Isoantibodies Graft Rejection Flow Cytometry Adult Male Middle Aged Graft Survival Humans Histocompatibility Machine Learning Histocompatibility Testing Kidney Transplantation Isoantigens Female
View on PubMed DOI

Building the drug-GO function network to screen significant candidate drugs for myasthenia gravis.

PloS one Apr 4, 2019
Myasthenia gravis (MG) is an autoimmune disease. In recent years, considerable evidence has indicated that Gene Ontology (GO) functions, especially GO-biological processes, have important effects on the mechanisms and treatments of different diseases...
Humans Immunosuppressive Agents Gene Ontology Adalimumab Gene Regulatory Networks Myasthenia Gravis Databases, Pharmaceutical Drug Repositioning Glucosamine Genetic Association Studies Pharmacogenomic Testing Carnosine Thalidomide Databases, Genetic Etanercept Organometallic Compounds Zinc Compounds
View on PubMed DOI
Popular Topics
Recent Journals