AIMC Topic: Lupus Erythematosus, Systemic

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Exploring genetic and immune cell dynamics in systemic lupus erythematosus patients with Epstein-Barr virus infection via machine learning.

Rheumatology (Oxford, England) May 1, 2025
OBJECTIVES: EBV is a widespread virus implicated in various diseases, including SLE. However, the specific genes and pathways altered in SLE patients with EBV infection remain unclear. We aimed to identify key genes and immune cells in SLE patients w...
Female Gene Expression Profiling Humans Machine Learning Herpesvirus 4, Human Lupus Erythematosus, Systemic Membrane Proteins Epstein-Barr Virus Infections
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Machine learning-driven immunophenotypic stratification of mixed connective tissue disease, corroborating the clinical heterogeneity.

Rheumatology (Oxford, England) Mar 1, 2025
OBJECTIVE: The objective of this study was to stratify patients with MCTD, based on their immunophenotype.
Female Adult Humans Machine Learning Transcriptome Immunophenotyping Lupus Erythematosus, Systemic Myositis Male Middle Aged Scleroderma, Systemic Mixed Connective Tissue Disease
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Explainable deep neural networks for predicting sample phenotypes from single-cell transcriptomics.

Briefings in bioinformatics Nov 22, 2024
Recent advances in single-cell RNA-Sequencing (scRNA-Seq) technologies have revolutionized our ability to gather molecular insights into different phenotypes at the level of individual cells. The analysis of the resulting data poses significant chall...
Lupus Erythematosus, Systemic Alzheimer Disease Single-Cell Analysis Sequence Analysis, RNA SARS-CoV-2 Gene Expression Profiling Transcriptome Deep Learning Algorithms Humans Phenotype Neural Networks, Computer COVID-19
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A Comprehensive Natural Language Processing Pipeline for the Chronic Lupus Disease.

Studies in health technology and informatics Aug 22, 2024
Electronic Health Records (EHRs) contain a wealth of unstructured patient data, making it challenging for physicians to do informed decisions. In this paper, we introduce a Natural Language Processing (NLP) approach for the extraction of therapies, d...
Lupus Erythematosus, Systemic Humans Chronic Disease Data Mining Electronic Health Records Natural Language Processing
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Identification of novel biomarkers for childhood-onset systemic lupus erythematosus using machine learning algorithms and immune infiltration analysis.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) Aug 1, 2024
BACKGROUND: Childhood-onset systemic lupus erythematosus (cSLE) is a chronic autoimmune disease that is often more severe than adult-onset SLE and is challenging to diagnose due to its variable presentation and lack of specific diagnostic tests.
Humans Support Vector Machine Machine Learning Gene Expression Profiling Databases, Genetic Lupus Erythematosus, Systemic Algorithms Child Biomarkers
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Fatigue Detection with Machine Learning Approaches using Data from Wearable Devices.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference Jul 1, 2024
Severe and chronic fatigue is one of the top symptoms in patients with non-communicable chronic immune-mediated inflammatory diseases like Systemic Lupus Erythematosus (SLE) and Sjögren's disease (SjD). The majority of fatigue assessment approaches r...
Male Humans Accelerometry Middle Aged Machine Learning Female Wearable Electronic Devices Fatigue Adult Lupus Erythematosus, Systemic
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Automated and flexible identification of complex disease: building a model for systemic lupus erythematosus using noisy labeling.

Journal of the American Medical Informatics Association : JAMIA Jan 1, 2019
UNLABELLED: Accurate and efficient identification of complex chronic conditions in the electronic health record (EHR) is an important but challenging task that has historically relied on tedious clinician review and oversimplification of the disease....
ROC Curve Lupus Erythematosus, Systemic Humans Algorithms Machine Learning Electronic Health Records
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