AIMC Topic: Machine Learning

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Machine Learning and Network Analyses Reveal Disease Subtypes of Pancreatic Cancer and their Molecular Characteristics.

Scientific reports
Given that the biological processes governing the oncogenesis of pancreatic cancers could present useful therapeutic targets, there is a pressing need to molecularly distinguish between different clinically relevant pancreatic cancer subtypes. To add...

Single-cell dispensing and 'real-time' cell classification using convolutional neural networks for higher efficiency in single-cell cloning.

Scientific reports
Single-cell dispensing for automated cell isolation of individual cells has gained increased attention in the biopharmaceutical industry, mainly for production of clonal cell lines. Here, machine learning for classification of cell images is applied ...

Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease.

NeuroImage. Clinical
Alzheimer's disease (AD) is characterised by a dynamic process of neurocognitive changes from normal cognition to mild cognitive impairment (MCI) and progression to dementia. However, not all individuals with MCI develop dementia. Predicting whether ...

Person Re-Identification with Feature Pyramid Optimization and Gradual Background Suppression.

Neural networks : the official journal of the International Neural Network Society
Compared with face recognition, the performance of person re-identification (re-ID) is still far from practical application. Among various interferences, there are two factors seriously limiting the performance improvement, i.e., the feature discrimi...

Batch Mode Active Learning on the Riemannian Manifold for Automated Scoring of Nuclear Pleomorphism in Breast Cancer.

Artificial intelligence in medicine
Breast cancer is the most prevalent invasive type of cancer among women. The mortality rate of the disease can be reduced considerably through timely prognosis and felicitous treatment planning, by utilizing the computer aided detection and diagnosis...

Deep Learning-Based Single-Cell Optical Image Studies.

Cytometry. Part A : the journal of the International Society for Analytical Cytology
Optical imaging technology that has the advantages of high sensitivity and cost-effectiveness greatly promotes the progress of nondestructive single-cell studies. Complex cellular image analysis tasks such as three-dimensional reconstruction call for...

Overlooked pitfalls in multi-class machine learning classification in radiation oncology and how to avoid them.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
In radiation oncology, Machine Learning classification publications are typically related to two outcome classes, e.g. the presence or absence of distant metastasis. However, multi-class classification problems also have great clinical relevance, e.g...

Design of (quinolin-4-ylthio)carboxylic acids as new Escherichia coli DNA gyrase B inhibitors: machine learning studies, molecular docking, synthesis and biological testing.

Computational biology and chemistry
Spread of multidrug-resistant Escherichia coli clinical isolates is a main problem in the treatment of infectious diseases. Therefore, the modern scientific approaches in decision this problem require not only a prevention strategy, but also the deve...

A Comparative Classification Analysis of Abdominal Aortic Aneurysms by Machine Learning Algorithms.

Annals of biomedical engineering
The objective of this work was to perform image-based classification of abdominal aortic aneurysms (AAA) based on their demographic, geometric, and biomechanical attributes. We retrospectively reviewed existing demographics and abdominal computed tom...

A machine-learning approach to predicting hypotensive events in ICU settings.

Computers in biology and medicine
BACKGROUND: Predicting hypotension well in advance provides physicians with enough time to respond with proper therapeutic measures. However, the real-time prediction of hypotension with high positive predictive value (PPV) is a challenge. This is du...