Clinical trials are widely considered the gold standard for treatment evaluation, and they can be highly expensive in terms of time and money. The efficiency of clinical trials can be improved by incorporating information from baseline covariates tha...
We present two approaches for the computation of hydrogen bond acceptor strengths, one by machine-learning and one by a composite quantum-mechanical protocol, both based on the well-established pK scale and dataset. The QM calculations after a necess...
Computer methods and programs in biomedicine
Nov 24, 2018
BACKGROUND AND OBJECTIVE: Computer Aided Diagnosis (CAD) techniques have widely been used in research to detect the neurological abnormalities and improve the consistency of diagnosis and treatment in medicine. In this study, a new CAD system based o...
INTRODUCTION: Artificial intelligence (AI) is a field of mathematical engineering which has potential to enhance healthcare through new care delivery strategies, informed decision making and facilitation of patient engagement. Machine learning (ML) i...
Paraquat (PQ) poisoning seriously harms the health of humanity. An effective diagnostic method for paraquat poisoned patients is a crucial concern. Nevertheless, it's difficult to identify the patients with low intake of PQ or delayed treatment. Here...
OBJECTIVES: Finding recent clinical studies that warrant changes in clinical practice ("high impact" clinical studies) in a timely manner is very challenging. We investigated a machine learning approach to find recent studies with high clinical impac...
BACKGROUND: Epilepsy is a neurological disease characterized by unprovoked seizures in the brain. The recent advances in sensor technologies allow researchers to analyze the collected biological records to improve the treatment of epilepsy. Electroen...
IEEE/ACM transactions on computational biology and bioinformatics
Nov 21, 2018
Transcription factors (TFs) are the major components of human gene regulation. In particular, they bind onto specific DNA sequences and regulate neighborhood genes in different tissues at different developmental stages. Non-synonymous single nucleoti...
Risk analysis : an official publication of the Society for Risk Analysis
Nov 21, 2018
Next-generation sequencing (NGS) data present an untapped potential to improve microbial risk assessment (MRA) through increased specificity and redefinition of the hazard. Most of the MRA models do not account for differences in survivability and vi...
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