BACKGROUND: High-resolution esophageal manometry (HRM) is essential for diagnosing esophageal motility disorders, affecting 10%-15% of patients with dysphagia. Current interpretation via the Chicago Classification remains challenging, with interobser...
BACKGROUND: Patients with acute coronary syndrome (ACS) who undergo percutaneous coronary intervention (PCI) remain at high risk for major adverse cardiovascular events (MACE). Conventional risk scores may not capture dynamic or nonlinear changes in ...
Emerging evidence suggests that gut microbiota dysbiosis is associated with bone metabolism disorders, including osteopenia (ON) and osteoporosis (OP). However, multi-cohort integrated and association analyses remain underexplored. We conducted a com...
Analytical methods : advancing methods and applications
Nov 27, 2025
Cellular surface receptors are commonly used as diagnostic and prognostic biomarkers for many infectious diseases. Benchtop clinical instruments, , flow cytometers and fluorescence microscopes are commonly employed for identification and quantificati...
Effective recycling of spent LiNixCoyMn1-x-yO2 (NCM) battery is crucial to ensure sustainability of the lithium-ion battery industry. However, recycling is inherent with multiple operational steps and many effective factors. It is difficult to optimi...
Journal of chemical information and modeling
Nov 26, 2025
Incorporating five or more metals into a single structure creates a new family of alloys, high-entropy alloys (HEAs), which hold several exceptional properties, such as outstanding stabilities and continuous electronic structures, making them promisi...
Journal of chemical information and modeling
Nov 26, 2025
Protein structure database search has become increasingly challenging due to the growing number of experimental and computational structures. We introduce mTM-align2, a novel two-step approach for rapid and accurate protein structure database search....
UNLABELLED: Matrix-assisted laser desorption-ionization-time of flight (MALDI-TOF) mass spectra can be used to predict antimicrobial resistance (AMR) using machine learning (ML). This study aimed to validate the performance of ML models for AMR predi...
Journal of the American Chemical Society
Nov 26, 2025
The implementation of high-throughput methods for fuelling the design of effective nanocarriers for RNA delivery remains challenging. Traditional experimental screening is resource-intensive, while purely computational approaches face limitations, su...
Continuous fetal movement monitoring in late pregnancy may improve fetal wellbeing and pregnancy outcomes. While fetal movements can be visualized with ultrasound, it is intermittent and limited to clinical settings. Inertial measurement units may en...
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