Synthetic cells (SCs), developed through bottom-up synthetic biology, hold great potential for biomedical applications, with the promise of replacing malfunctioning natural cells and treating diseases with spatiotemporal control. Currently, most SC s...
Advances in single-cell '-omics' allow unprecedented insights into the transcriptional profiles of individual cells and, when combined with large-scale perturbation screens, enable measuring of the effect of targeted perturbations on the whole transc...
: Long non-coding RNAs (lncRNAs) play a crucial regulatory role in plant trait expression and disease management, making their accurate prediction a key research focus for guiding biological experiments. While extensive studies have been conducted on...
International journal of molecular sciences
Mar 31, 2025
Neutrophil extracellular traps (NETs) play a key role in the development of bronchopulmonary dysplasia (BPD), yet their molecular mechanisms in contributing to BPD remain unexplored. Using the GSE32472 dataset, which includes 100 blood samples from p...
BACKGROUND: High-grade gliomas are among the most aggressive and deadly brain tumors, highlighting the critical need for improved prognostic markers and predictive models. Recent studies have identified the expression of IL7R as a significant risk fa...
BMC medical informatics and decision making
Mar 31, 2025
BACKGROUND: Sepsis, a severe systemic response to infection, frequently results in adverse outcomes, underscoring the urgency for prompt and accurate prognostic tools. Machine learning methods such as logistic regression, random forests, and CatBoost...
BACKGROUND: Feed efficiency (FE) is an essential trait in livestock species because of the constant demand to increase the productivity and sustainability of livestock production systems. A better understanding of the biological mechanisms associated...
Machine learning is frequently used to make decisions based on big data. Among these techniques, random forest is particularly prominent. Although random forest is known to have many advantages, one aspect that is often overseen is that it is a non-d...
The aim of this study was to establish the optimal prediction model by comparing the prediction effect of 6 kinds of prediction models containing biochemical indexes on the risk of osteoporosis in middle-aged and elderly women in Tibet. This study ad...
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