The journal of physical chemistry letters
Jun 16, 2025
Atomic charge is crucial in drug design for analyzing reactive sites and interactions between ligands and targets. While quantum mechanical methods offer high accuracy, they are generally computationally costly. Conversely, empirical approaches, whil...
European journal of medical research
Jun 16, 2025
OBJECTIVES: The early diagnosis and immunoregulatory mechanisms of active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remain unclear, and the role of metabolic genes in host-pathogen interactions requires further investigation.
Mikrochimica acta
Jun 16, 2025
Cancer remains one of the most deadly diseases in the world, requiring constant growth and improvements in therapeutic strategies. Traditional cancer treatments, such as chemotherapy, radiotherapy, and surgery, have limitations like off-target releas...
Scientific reports
Jun 16, 2025
Dysarthria frequently occurs in individuals with disorders such as stroke, Parkinson's disease, cerebral palsy, and other neurological disorders. Well-timed detection and management of dysarthria in these patients is imperative for efficiently handli...
Anais da Academia Brasileira de Ciencias
Jun 16, 2025
This research focuses on predicting cardiovascular disease using machine learning classification strategies. The study presents a unique approach by integrating multiple machine learning techniques, leveraging the strengths of Random Forest and Gradi...
The journal of physical chemistry letters
Jun 15, 2025
Accurate and early detection of C-peptide, a stable biomarker indicative of diabetes, is crucial for disease diagnosis, treatment, and prevention. This study explores a novel detection methodology using solid-state nanopore technology coupled with ma...
Epigenetics & chromatin
Jun 14, 2025
DNA methylation is a fundamental epigenetic modification that regulates gene expression and maintains genomic stability. Consequently, DNA methylation remains a key biomarker in cancer research, playing a vital role in diagnosis, prognosis, and tailo...
Clinical and experimental medicine
Jun 14, 2025
The SARS-CoV-2 RNA virus, with its rapid spread and frequent genetic changes, has posed unparalleled obstacles for public health and treatment efforts. Early diagnosis of the disease and the development of effective treatment strategies are the main ...
Metabolomics : Official journal of the Metabolomic Society
Jun 14, 2025
INTRODUCTION: Breast cancer is the most common cancer among women, with its burden increasing over the past decades. Early diagnosis significantly improves survival rates and reduces lethality. Innovative technologies are being developed for early de...
Drug design, development and therapy
Jun 14, 2025
OBJECTIVE: Alzheimer's disease poses a significant threat to human health. Currenttherapeutic medicines, while alleviate symptoms, fail to reverse the disease progression or reduce its harmful effects, and exhibit toxicity and side effects such as ga...