Following complete mesocolic excision (CME), heart failure (HF) emerges as a significant complication, exerting substantial impacts on both short-term and long-term patient prognoses. The primary objective of our investigation was to develop a machin...
Advances in in vivo Ca imaging using miniature microscopes have enabled researchers to study single-neuron activity in freely moving animals. Tools such as Minian and CalmAn have been developed to convert Ca visual signals to numerical data, collecti...
Data used to understand knee osteoarthritis (KOA) often involves knee-level, rather than person-level information. Failure to account for the correlation between joints within a person may lead to inaccurate inferences. The aim of this study was to d...
In recent times, chronic kidney cancer has been considered a significant cause of cancer, and Renal Cell Carcinoma (RCC) has become a significant prevalent among various kidney cancer conditions. The analysis of kidney cancer, an important and often ...
Clinica chimica acta; international journal of clinical chemistry
Jul 14, 2025
BACKGROUND: Necroptosis is inflammatorily sparked and closely associated with sepsis, but the crosstalk between necroptosis and inflammation in sepsis has rarely been studied in depth. This study is designed to reveal the role of necroptosis in the p...
Alzheimer's disease (AD) is a multifactorial neurological disorder accounting for the cognitive decline in the patients. The disease is linked to numerous pathological factors including hyperactivation of acetylcholinesterase (AChE) and monoamine oxi...
Population aging presents significant health challenges and socioeconomic burdens globally, driving an increased demand for precision health management. In the era of big data, the exponential growth of health information is accelerating advances in ...
Fishes of various trophic levels play an important role in the stability and balance of aquatic ecosystems. Metal contaminants can impair the survival and population fitness of fish at elevated concentrations. When universal water quality criteria (W...
High-throughput screening (HTS) remains central to small molecule lead discovery, but increasing assay complexity challenges the screening of large compound libraries. While retrospective studies have assessed active-learning-guided screening, extens...
Journal of chemical theory and computation
Jul 14, 2025
In this study, we propose a Kernel-PCA model designed to capture structure-function relationships in a protein. This model also enables the ranking of reaction coordinates according to their impact on protein properties. By leveraging machine learnin...
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