AIMC Topic: Membrane Proteins

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Accurate flexible refinement for atomic-level protein structure using cryo-EM density maps and deep learning.

Briefings in bioinformatics Mar 10, 2022
With the rapid progress of deep learning in cryo-electron microscopy and protein structure prediction, improving the accuracy of the protein structure model by using a density map and predicted contact/distance map through deep learning has become an...
Membrane Proteins Models, Molecular Protein Conformation Cryoelectron Microscopy Deep Learning
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A deep learning-based approach to model anomalous diffusion of membrane proteins: the case of the nicotinic acetylcholine receptor.

Briefings in bioinformatics Jan 17, 2022
We present a concatenated deep-learning multiple neural network system for the analysis of single-molecule trajectories. We apply this machine learning-based analysis to characterize the translational diffusion of the nicotinic acetylcholine receptor...
Deep Learning Membrane Proteins Diffusion Cell Membrane Receptors, Nicotinic
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Computational Approaches for Investigating Disease-causing Mutations in Membrane Proteins: Database Development, Analysis and Prediction.

Current topics in medicinal chemistry Jan 1, 2022
Membrane proteins (MPs) play an essential role in a broad range of cellular functions, serving as transporters, enzymes, receptors, and communicators, and about ~60% of membrane proteins are primarily used as drug targets. These proteins adopt either...
Databases, Protein Mutation Protein Conformation, alpha-Helical Humans Computational Biology Membrane Proteins Machine Learning Databases, Factual
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Precise estimation of residue relative solvent accessible area from Cα atom distance matrix using a deep learning method.

Bioinformatics (Oxford, England) Dec 22, 2021
MOTIVATION: The solvent accessible surface is an essential structural property measure related to the protein structure and protein function. Relative solvent accessible area (RSA) is a standard measure to describe the degree of residue exposure in t...
Deep Learning Membrane Proteins Solvents
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PolarProtPred: predicting apical and basolateral localization of transmembrane proteins using putative short linear motifs and deep learning.

Bioinformatics (Oxford, England) Dec 7, 2021
MOTIVATION: Cell polarity refers to the asymmetric organization of cellular components in various cells. Epithelial cells are the best-known examples of polarized cells, featuring apical and basolateral membrane domains. Mounting evidence suggests th...
Epithelial Cells Cell Membrane COVID-19 Deep Learning Humans Membrane Proteins
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Evaluation of Combined Cancer Markers With Lactate Dehydrogenase and Application of Machine Learning Algorithms for Differentiating Benign Disease From Malignant Ovarian Cancer.

Cancer control : journal of the Moffitt Cancer Center Jan 1, 2021
BACKGROUND: The differential diagnosis of ovarian cancer is important, and there has been ongoing research to identify biomarkers with higher performance. This study aimed to evaluate the diagnostic utility of combinations of cancer markers classifie...
Neutrophils Early Detection of Cancer Diagnosis, Differential Middle Aged ROC Curve Membrane Proteins CA-125 Antigen Leukocyte Count WAP Four-Disulfide Core Domain Protein 2 Ovarian Neoplasms Lymphocytes L-Lactate Dehydrogenase Humans Adult Biomarkers, Tumor Machine Learning Female
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Anti-inflammatory and antibacterial activities of P. petiolosa (Christ) Ching ethyl acetate extract against S. aureus in mice.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
P. petiolosa as a typical Chinese herbal medicine has been generally utilized as Chinese native medicine formulation for treatment of chronic bronchitis, bronchial asthma and pneumoconiosis. The objective of this study was to evaluate the anti-inflam...
Nitric Oxide Synthase Type II Pneumonia, Staphylococcal Polypodiaceae Bacterial Load Heme Oxygenase-1 Staphylococcus aureus Inflammation Mediators Acetates Anti-Bacterial Agents Lung Disease Models, Animal Plant Leaves Solvents Tumor Necrosis Factor-alpha Plant Extracts Mice, Inbred BALB C Anti-Inflammatory Agents Animals Membrane Proteins
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Identifying short disorder-to-order binding regions in disordered proteins with a deep convolutional neural network method.

Journal of bioinformatics and computational biology Feb 1, 2019
Molecular recognition features (MoRFs) are key functional regions of intrinsically disordered proteins (IDPs), which play important roles in the molecular interaction network of cells and are implicated in many serious human diseases. Identifying MoR...
Intrinsically Disordered Proteins Binding Sites Membrane Proteins Databases, Protein Amino Acid Sequence Deep Learning Protein Binding Computational Biology Humans Neural Networks, Computer
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New Computational Tool Based on Machine-learning Algorithms for the Identification of Rhinovirus Infection-Related Genes.

Combinatorial chemistry & high throughput screening Jan 1, 2019
BACKGROUND: Human rhinovirus has different identified serotypes and is the most common cause of cold in humans. To date, many genes have been discovered to be related to rhinovirus infection. However, the pathogenic mechanism of rhinovirus is difficu...
Gene Expression Profiling Computational Biology Membrane Proteins Support Vector Machine Suppressor of Cytokine Signaling 1 Protein Humans Picornaviridae Infections
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The dose-response association between estimated glomerular filtration rate and prognosis of patients with ST-segment elevation myocardial infarction from rural areas of China's Liaoning province.

Medicine Dec 1, 2017
We aimed to investigate the dose-response associations between chronic kidney disease (CKD), and short and long-term cardiovascular outcomes, to characterize these associations by drawing dose-response curves based on a Chinese rural ST-segment eleva...
Hospital Mortality Logistic Models Membrane Proteins Glomerular Filtration Rate Age Factors Rural Population Renal Insufficiency, Chronic Female Comorbidity Humans Aged Severity of Illness Index Aged, 80 and over Biomarkers Male China Adult Proportional Hazards Models ST Elevation Myocardial Infarction Prognosis Cardiovascular Diseases Hyperlipidemias Middle Aged Drosophila Proteins
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