AIMC Topic: Mesenchymal Stem Cells
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Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment.
Nature communications
Jul 4, 2025
Current approaches for bone repair predominantly target localized delivery of growth factors that are aimed at the coupling of angiogenesis and osteogenesis. However, delayed revascularization and regeneration of critical-sized bone defects are still...
Molecular mechanisms of deer antler in promoting osteogenic differentiation of human mesenchymal stem cells via JUN modulation.
Frontiers in immunology
May 29, 2025
BACKGROUND: Traditional Chinese medicine and food deer antler has been extensively used in bone regeneration, but its molecular mechanisms remain poorly understood. Preliminary investigations suggest deer antler contains bioactive compounds that infl...
Nucleic acid spheres for treating capillarisation of liver sinusoidal endothelial cells in liver fibrosis.
Nature communications
May 15, 2025
Liver sinusoidal endothelial cells (LSECs) lose their characteristic fenestrations and become capillarized during the progression of liver fibrosis. Mesenchymal stem cell (MSC) transplantation can reverse this capillarization and reduce fibrosis, but...
Predicting genes associated with ossification of the posterior longitudinal ligament using graph attention network.
Methods (San Diego, Calif.)
Apr 4, 2025
Ossification of the posterior longitudinal ligament is a degenerative disease that severely impacts the spine, with a complex pathogenesis involving the interplay of multiple genes. This study utilizes a combination of graph neural networks and deep ...
Mechanisms Tackling Salivary Gland Diseases with Extracellular Vesicle Therapies.
Journal of dental research
Mar 25, 2025
Extracellular vesicles (EVs) are lipid-enclosed particles released from cells, containing lipids, DNA, RNA, metabolites, and cytosolic and cell surface proteins. EVs support intercellular communication and orchestrate organogenesis by transferring bi...
Comparative Study of Deep Transfer Learning Models for Semantic Segmentation of Human Mesenchymal Stem Cell Micrographs.
International journal of molecular sciences
Mar 6, 2025
The aim of this study is to conduct a comparative assessment of the effectiveness of neural network models-U-Net, DeepLabV3+, SegNet and Mask R-CNN-for the semantic segmentation of micrographs of human mesenchymal stem cells (MSCs). A dataset of 320 ...
Machine learning aided UV absorbance spectroscopy for microbial contamination in cell therapy products.
Scientific reports
Mar 4, 2025
We demonstrate the feasibility of machine-learning aided UV absorbance spectroscopy for in-process microbial contamination detection during cell therapy product (CTP) manufacturing. This method leverages a one-class support vector machine to analyse ...
Advancing regenerative medicine: the Aceman system's pioneering automation and machine learning in mesenchymal stem cell biofabrication.
Biofabrication
Feb 27, 2025
Mesenchymal stem cells (MSCs) are pivotal in advancing regenerative medicine; however, the large-scale production of MSCs for clinical applications faces significant challenges related to efficiency, cost, and quality assurance. We introduce the Auto...
An object detection-based model for automated screening of stem-cells senescence during drug screening.
Neural networks : the official journal of the International Neural Network Society
Nov 23, 2024
Deep learning-based cell senescence detection is crucial for accurate quantitative analysis of senescence assessment. However, senescent cells are small in size and have little differences in appearance and shape in different states, which leads to i...
Magnetic soft microrobots for erectile dysfunction therapy.
Proceedings of the National Academy of Sciences of the United States of America
Nov 18, 2024
Erectile dysfunction (ED) is a major threat to male fertility and quality of life, and mesenchymal stromal cells (MSCs) are a promising therapeutic option. However, therapeutic outcomes are compromised by low MSC retention and survival rates in corpu...
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