AIMC Topic: Metabolome
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Uncovering subtype-specific metabolic signatures in breast cancer through multimodal integration, attention-based deep learning, and self-organizing maps.
Scientific reports
Jul 1, 2025
This study integrates multimodal metabolomic data from three platforms-LC-MS, GC-MS, and NMR-to systematically identify biomarkers distinguishing breast cancer subtypes. A feedforward attention-based deep learning model effectively selected 99 signif...
Targeted metabolomics reveals bioactive inflammatory mediators from gut into blood circulation in children with NAFLD.
NPJ biofilms and microbiomes
Jul 1, 2025
Altered gut metabolites are important for the inflammatory progression in children with NAFLD. Fecal and plasma samples were collected from 145 subjects including 53 non-alcoholic fatty liver (NAFL), 39 nonalcoholic steatohepatitis (NASH) and 53 obes...
Comprehensive statistical and machine learning framework for identification of metabolomic biomarkers in breast cancer.
Metabolomics : Official journal of the Metabolomic Society
Jun 14, 2025
INTRODUCTION: Breast cancer is the most common cancer among women, with its burden increasing over the past decades. Early diagnosis significantly improves survival rates and reduces lethality. Innovative technologies are being developed for early de...
Metabolic profiles in laryngeal cancer defined two distinct molecular subtypes with divergent prognoses.
Frontiers in immunology
May 22, 2025
BACKGROUND: Laryngeal cancer (LCA) is the second most common type of head and neck malignancy, characterized by high recurrence rates and poor overall survival (OS). However, progress in curing LCA through molecular-targeted diagnostics and therapies...
Metabolic signature of COVID-19 progression: potential prognostic markers for severity and outcome.
Metabolomics : Official journal of the Metabolomic Society
May 21, 2025
INTRODUCTION: There are significant challenges remain in accurately categorizing the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients.
Brassica microgreens shape gut microbiota and functional metabolite profiles in a species-related manner: A multi-omics approach following in vitro gastrointestinal digestion and large intestine fermentation.
Microbiological research
May 19, 2025
Brassicaceae microgreens constitute a novel and promising source of bioactive compounds, such as polyphenols and glucosinolates. In this work, an integrative computational approach was performed to decipher the interaction between bioaccessible micro...
Deciphering microbial and metabolic influences in gastrointestinal diseases-unveiling their roles in gastric cancer, colorectal cancer, and inflammatory bowel disease.
Journal of translational medicine
May 16, 2025
INTRODUCTION: Gastrointestinal disorders (GIDs) affect nearly 40% of the global population, with gut microbiome-metabolome interactions playing a crucial role in gastric cancer (GC), colorectal cancer (CRC), and inflammatory bowel disease (IBD). This...
GLIO-Select: Machine Learning-Based Feature Selection and Weighting of Tissue and Serum Proteomic and Metabolomic Data Uncovers Sex Differences in Glioblastoma.
International journal of molecular sciences
May 2, 2025
Glioblastoma (GBM) is a fatal brain cancer known for its rapid and aggressive growth, with some studies indicating that females may have better survival outcomes compared to males. While sex differences in GBM have been observed, the underlying biolo...
Transcripts and genomic intervals associated with variation in metabolite abundance in maize leaves under field conditions.
BMC genomics
May 1, 2025
Plants exhibit extensive environment-dependent intraspecific metabolic variation, which likely plays a role in determining variation in whole plant phenotypes. However, much of the work seeking to use natural variation to link genes and transcript's ...
Metabolomic signatures of pathogen suppression effect of Baltic eelgrass meadows in surrounding seawater.
The Science of the total environment
Apr 27, 2025
Organic molecules exuded into water column by marine organisms represent a significant portion of marine dissolved organic matter (DOM) that modulates biochemical interactions. Secreted allelochemicals have been suggested to be involved in regulation...
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