AIMC Topic: Mice
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Construction and characterization of recombinant adenovirus carrying a mouse TIGIT-GFP gene.
Genetics and molecular research : GMR
Dec 29, 2015
Recombinant adenovirus vector systems have been used extensively in protein research and gene therapy. However, the construction and characterization of recombinant adenovirus is a tedious and time-consuming process. TIGIT is a recently discovered im...
Monitoring vascular normalization induced by antiangiogenic treatment with (18)F-fluoromisonidazole-PET.
Molecular oncology
Dec 22, 2015
BACKGROUND: Rationalization of antiangiogenics requires biomarkers. Vascular re-normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular...
Benzimidazoles
Antimetabolites, Antineoplastic
Deoxycytidine
Humans
Cell Line, Tumor
Pancreatic Neoplasms
Gemcitabine
Neovascularization, Pathologic
Mice
Female
Pancreas
Misonidazole
Breast
Angiogenesis Inhibitors
Breast Neoplasms
Cell Hypoxia
Mice, Nude
Positron-Emission Tomography
Fluorine Radioisotopes
Animals
Quinolones
Computational identification of piRNA targets on mouse mRNAs.
Bioinformatics (Oxford, England)
Dec 16, 2015
MOTIVATION: PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that are highly abundant in the germline. One important role of piRNAs is to defend genome integrity by guiding PIWI proteins to silence transposable elements (TEs), whic...
Vocal Fold Augmentation with Beta Glucan Hydrogel Cross-Linked by γ Irradiation for Enhanced Duration of Effect: In Vivo Animal Study.
BioMed research international
Dec 13, 2015
This study explored a novel strategy to restore the vocal gap by using cross-linked β-glucan hydrogel by γ-irradiation. An aqueous solution of 5 wt% β-glucan was prepared and cross-linked using (60)Co γ irradiation. Ten nude mice were injected with 0...
Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification.
Methods (San Diego, Calif.)
Dec 11, 2015
Biologists increasingly use co-culture systems in which two or more cell types are grown in cell culture together in order to better model cells' native microenvironments. Co-cultures are often required for cell survival or proliferation, or to maint...
LedPred: an R/bioconductor package to predict regulatory sequences using support vector machines.
Bioinformatics (Oxford, England)
Dec 1, 2015
UNLABELLED: Supervised classification based on support vector machines (SVMs) has successfully been used for the prediction of cis-regulatory modules (CRMs). However, no integrated tool using such heterogeneous data as position-specific scoring matri...
Improved Classification of Lung Cancer Using Radial Basis Function Neural Network with Affine Transforms of Voss Representation.
PloS one
Dec 1, 2015
Lung cancer is one of the diseases responsible for a large number of cancer related death cases worldwide. The recommended standard for screening and early detection of lung cancer is the low dose computed tomography. However, many patients diagnosed...
Degradable Magnetic Composites for Minimally Invasive Interventions: Device Fabrication, Targeted Drug Delivery, and Cytotoxicity Tests.
Advanced materials (Deerfield Beach, Fla.)
Nov 25, 2015
Superparamagnetic nanoparticles and a functional, degradable polymer matrix based on poly(ethylene glycol) are combined to enable fully degradable magnetic microdevices for minimally invasive biomedical applications. A bioinspired helical microrobot ...
Systematic Analysis and Prediction of In Situ Cross Talk of O-GlcNAcylation and Phosphorylation.
BioMed research international
Oct 27, 2015
Reversible posttranslational modification (PTM) plays a very important role in biological process by changing properties of proteins. As many proteins are multiply modified by PTMs, cross talk of PTMs is becoming an intriguing topic and draws much at...
The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2.
Research in veterinary science
Oct 26, 2015
Arctigenin (ACT) is a phenylpropanoid dibenzylbutyrolactone lignan extracted from the traditional herb Arctium lappa L. (Compositae) with anti-viral and anti-inflammatory effects. Here, we investigated the antiviral activity of ACT found in tradition...
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