AIMC Topic: Mice

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Preclinical efficacy of a cell division protein candidate gonococcal vaccine identified by artificial intelligence.

mBio Oct 31, 2023
Vaccines to curb the global spread of multidrug-resistant gonorrhea are urgently needed. Here, 26 vaccine candidates identified by an artificial intelligence-driven platform (Efficacy Discriminative Educated Network[EDEN]) were screened for efficacy ...
Artificial Intelligence Female Animals Vagina Antigens, Bacterial Cell Division Bacterial Vaccines Neisseria gonorrhoeae Gonorrhea Antibodies, Bacterial Mice Disease Models, Animal Bacterial Proteins
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DeepGAMI: deep biologically guided auxiliary learning for multimodal integration and imputation to improve genotype-phenotype prediction.

Genome medicine Oct 31, 2023
BACKGROUND: Genotypes are strongly associated with disease phenotypes, particularly in brain disorders. However, the molecular and cellular mechanisms behind this association remain elusive. With emerging multimodal data for these mechanisms, machine...
Mice Genotype Alzheimer Disease Neural Networks, Computer Machine Learning Phenotype Animals
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PINK1 dominated mitochondria associated genes signature predicts abdominal aortic aneurysm with metabolic syndrome.

Biochimica et biophysica acta. Molecular basis of disease Oct 30, 2023
Abdominal aortic aneurysm (AAA) is typically asymptomatic but a devastating cardiovascular disorder, with overall mortality exceeding 80 % once it ruptures. Some patients with AAA may also have comorbid metabolic syndrome (MS), suggesting a potential...
Mitochondria Protein Kinases Humans Animals Mice Metabolic Syndrome Lipopolysaccharides Aortic Aneurysm, Abdominal
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Anti-inflammatory and urease inhibitory iridoid glycosides from Nyctanthes arbor-tristis Linn.

Journal of ethnopharmacology Oct 30, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: Nyctanthes arbor-tristis Linn. has been used by Ayruvedic physicians for the cure of different diseases including ulcers, gastric and inflammatory diseases.
Molecular Docking Simulation Mice Plant Extracts Iridoid Glycosides Tumor Necrosis Factor-alpha Reactive Oxygen Species Kinetics Animals Anti-Inflammatory Agents Urease
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E. globulus leaf EO exhibits anti-inflammatory effects by regulating GSDMD-mediated pyroptosis, thereby alleviating neurological impairment and neuroinflammation in experimental stroke mice.

Journal of ethnopharmacology Oct 30, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatic and medicinal plants continue to be a major component of alternative and traditional medicine in the developing countries. Eucalyptus globulus (Labill.) is being employed to cultivation and production in China...
Rats, Sprague-Dawley Lipopolysaccharides Plant Leaves Anti-Infective Agents Neuroinflammatory Diseases Microglia NF-kappa B Mice Stroke Tumor Necrosis Factor-alpha Rats Infarction, Middle Cerebral Artery Interleukin-6 Anti-Inflammatory Agents Inflammation DNA-Binding Proteins Animals NLR Family, Pyrin Domain-Containing 3 Protein Pyroptosis
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The water-soluble subfraction from Artemisia argyi alleviates LPS-induced inflammatory responses via multiple pathways and targets in vitro and in vivo.

Journal of ethnopharmacology Oct 28, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: As a traditional Chinese medicine, Artemisia argyi has been used medicinally and eaten for more than 2000 years in China. It is widely reported in treating inflammatory diseases such as eczema, dermatitis, arthritis, a...
Artemisia Inflammation Mice Anti-Inflammatory Agents Animals Proto-Oncogene Proteins c-akt RNA, Messenger Lipopolysaccharides Molecular Docking Simulation Matrix Metalloproteinase 9 Plant Extracts NF-kappa B Water
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Recognition and reconstruction of cell differentiation patterns with deep learning.

PLoS computational biology Oct 27, 2023
Cell lineage decisions occur in three-dimensional spatial patterns that are difficult to identify by eye. There is an ongoing effort to replicate such patterns using mathematical modeling. One approach uses long ranging cell-cell communication to rep...
Models, Theoretical Cell Differentiation Animals Deep Learning Mice Neural Networks, Computer Algorithms
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Image Denoising of Low-Dose PET Mouse Scans with Deep Learning: Validation Study for Preclinical Imaging Applicability.

Molecular imaging and biology Oct 24, 2023
PURPOSE: Positron emission tomography (PET) image quality can be improved by higher injected activity and/or longer acquisition time, but both may often not be practical in preclinical imaging. Common preclinical radioactive doses (10 MBq) have been ...
Algorithms Mice Positron-Emission Tomography Fluorodeoxyglucose F18 Phantoms, Imaging Animals Deep Learning Image Processing, Computer-Assisted
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Intravital microscopy visualizes innate immune crosstalk and function in tissue microenvironment.

European journal of immunology Oct 19, 2023
Significant advances have been made in the field of intravital microscopy (IVM) on myeloid cells due to the growing number of validated fluorescent probes and reporter mice. IVM provides a visualization platform to directly observe cell behavior and ...
Artificial Intelligence Animals Mice Immunity, Innate Cell Communication Intravital Microscopy
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U-Net based vessel segmentation for murine brains with small micro-magnetic resonance imaging reference datasets.

PloS one Oct 12, 2023
Identification and quantitative segmentation of individual blood vessels in mice visualized with preclinical imaging techniques is a tedious, manual or semiautomated task that can require weeks of reviewing hundreds of levels of individual data sets....
Mice Magnetic Resonance Imaging Brain Animals Image Processing, Computer-Assisted Neural Networks, Computer
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