AIMC Topic: Mice

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Deep learning based prediction of species-specific protein S-glutathionylation sites.

Biochimica et biophysica acta. Proteins and proteomics Mar 29, 2020
As a widespread and reversible post-translational modification of proteins, S-glutathionylation specifically generates the mixed disulfides between cysteine residues and glutathione, which regulates various biological processes including oxidative st...
Protein S Animals Deep Learning Mice Protein Processing, Post-Translational Glutathione Species Specificity Cysteine Humans Algorithms
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Machine Learning Techniques for Classifying the Mutagenic Origins of Point Mutations.

Genetics Mar 19, 2020
There is increasing interest in developing diagnostics that discriminate individual mutagenic mechanisms in a range of applications that include identifying population-specific mutagenesis and resolving distinct mutation signatures in cancer samples....
Mice Sequence Analysis, DNA Mutagens Nucleotide Motifs Machine Learning Animals Point Mutation Ethylnitrosourea
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Machine learning analysis of whole mouse brain vasculature.

Nature methods Mar 11, 2020
Tissue clearing methods enable the imaging of biological specimens without sectioning. However, reliable and scalable analysis of large imaging datasets in three dimensions remains a challenge. Here we developed a deep learning-based framework to qua...
Brain Animals Imaging, Three-Dimensional Mice Machine Learning
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A Deep Learning Approach for Automated Sleep-Wake Scoring in Pre-Clinical Animal Models.

Journal of neuroscience methods Mar 2, 2020
BACKGROUND: Experimental investigation of sleep-wake dynamics in animals is an important part of pharmaceutical development. Typically, it involves recording of electroencephalogram, electromyogram, locomotor activity, and electrooculogram. Visual id...
Sleep Models, Animal Deep Learning Sleep Stages Mice Rats Dogs Neural Networks, Computer Algorithms Animals
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Combining feature selection and shape analysis uncovers precise rules for miRNA regulation in Huntington's disease mice.

BMC bioinformatics Feb 24, 2020
BACKGROUND: MicroRNA (miRNA) regulation is associated with several diseases, including neurodegenerative diseases. Several approaches can be used for modeling miRNA regulation. However, their precision may be limited for analyzing multidimensional da...
Proteomics Disease Models, Animal MicroRNAs Neurons Gene Expression Regulation Trinucleotide Repeats Huntington Disease Animals RNA-Seq Mice Huntingtin Protein RNA, Messenger Humans Gene Knock-In Techniques Machine Learning Brain
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ChronoMID-Cross-modal neural networks for 3-D temporal medical imaging data.

PloS one Feb 21, 2020
ChronoMID-neural networks for temporally-varying, hence Chrono, Medical Imaging Data-makes the novel application of cross-modal convolutional neural networks (X-CNNs) to the medical domain. In this paper, we present multiple approaches for incorporat...
Female Animals Spatio-Temporal Analysis Deep Learning Neural Networks, Computer Mice, Inbred C57BL Imaging, Three-Dimensional Machine Learning Data Interpretation, Statistical Mice Bone Remodeling Models, Theoretical X-Ray Microtomography
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Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment.

Drug design, development and therapy Feb 20, 2020
BACKGROUND: Sanjie Zhentong capsule (SZC) offers excellent effect in treating adenomyosis (AM), which is a common and difficult gynecological disease in the clinic. However, the systematic analysis of its mechanism has not been carried out yet and fu...
Adenomyosis Lipopolysaccharides Cell Survival Drugs, Chinese Herbal Anti-Inflammatory Agents Neural Networks, Computer Animals Capsules Cells, Cultured Mice RAW 264.7 Cells Cytokines Nitric Oxide Databases, Pharmaceutical Medicine, Chinese Traditional
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Cellular and Molecular Probing of Intact Human Organs.

Cell Feb 13, 2020
Optical tissue transparency permits scalable cellular and molecular investigation of complex tissues in 3D. Adult human organs are particularly challenging to render transparent because of the accumulation of dense and sturdy molecules in decades-age...
Humans Brain Swine Female Deep Learning Aged, 80 and over Thyroid Gland Imaging, Three-Dimensional Limit of Detection Mice Animals Pancreas Staining and Labeling Male Optical Imaging Kidney Middle Aged Eye
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Investigating the gene expression profiles of cells in seven embryonic stages with machine learning algorithms.

Genomics Feb 8, 2020
The development of embryonic cells involves several continuous stages, and some genes are related to embryogenesis. To date, few studies have systematically investigated changes in gene expression profiles during mammalian embryogenesis. In this stud...
Mice Animals Embryonic Development Support Vector Machine Machine Learning Gene Expression Profiling Embryo, Mammalian Transcriptome Single-Cell Analysis
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Skilled reaching tasks for head-fixed mice using a robotic manipulandum.

Nature protocols Feb 7, 2020
Skilled forelimb behaviors are among the most important for studying motor learning in multiple species including humans. This protocol describes learned forelimb tasks for mice using a two-axis robotic manipulandum. Our device provides a highly comp...
Movement Forelimb Robotics Psychomotor Performance Head Biomechanical Phenomena Animals Mice
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