AIMC Topic: Microfluidic Analytical Techniques

Clear Filters Showing 61 to 70 of 82 articles

High-Quality Immunohistochemical Stains Through Computational Assay Parameter Optimization.

IEEE transactions on bio-medical engineering
Accurate profiling of tumors using immunohistochemistry (IHC) is essential in cancer diagnosis. The inferences drawn from IHC-stained images depend to a great extent on the quality of immunostaining, which is in turn affected strongly by assay parame...

Thread/paper- and paper-based microfluidic devices for glucose assays employing artificial neural networks.

Electrophoresis
This paper describes the fabrication of and data collection from two microfluidic devices: a microfluidic thread/paper based analytical device (μTPAD) and 3D microfluidic paper-based analytical device (μPAD). Flowing solutions of glucose oxidase (GOx...

Thread based electrofluidic platform for direct metabolite analysis in complex samples.

Analytica chimica acta
The application of electrophoresis upon commercial threads is investigated for development of low-cost diagnostics assays, designed for the matrix separation and quantification of low abundance metabolites in complex samples - in this work riboflavin...

Multiparameter mechanical and morphometric screening of cells.

Scientific reports
We introduce a label-free method to rapidly phenotype and classify cells purely based on physical properties. We extract 15 biophysical parameters from cells as they deform in a microfluidic stretching flow field via high-speed microscopy and apply m...

Machine Learning Based Single-Frame Super-Resolution Processing for Lensless Blood Cell Counting.

Sensors (Basel, Switzerland)
A lensless blood cell counting system integrating microfluidic channel and a complementary metal oxide semiconductor (CMOS) image sensor is a promising technique to miniaturize the conventional optical lens based imaging system for point-of-care test...

Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells.

Nature methods
Induced pluripotent stem cells (iPSCs) are an essential tool for modeling how causal genetic variants impact cellular function in disease, as well as an emerging source of tissue for regenerative medicine. The preparation of somatic cells, their repr...

Prescribed 3-D Direct Writing of Suspended Micron/Sub-micron Scale Fiber Structures via a Robotic Dispensing System.

Journal of visualized experiments : JoVE
A 3-axis dispensing system is utilized to control the initiating and terminating fiber positions and trajectory via the dispensing software. The polymer fiber length and orientation is defined by the spatial positioning of the dispensing system 3-axi...

Size Control in the Nanoprecipitation Process of Stable Iodine (¹²⁷I) Using Microchannel Reactor-Optimization by Artificial Neural Networks.

AAPS PharmSciTech
In this study, nanosuspension of stable iodine ((127)I) was prepared by nanoprecipitation process in microfluidic devices. Then, size of particles was optimized using artificial neural networks (ANNs) modeling. The size of prepared particles was eval...

Microfluidics-based label-free SERS profiling of exosomes with machine learning for osteosarcoma diagnosis.

Talanta
Osteosarcoma (OS) calls for early diagnosis to significantly improve patient survival rates. Exosomes hold significant potential as noninvasive biomarkers for the early diagnosis of cancer. Here, we design a microfluidic device to purify and analyze ...

Deep learning-assisted 10-μL single droplet-based viscometry for human aqueous humor.

Biosensors & bioelectronics
Probing the viscosity of human aqueous humor is crucial for optimizing micro-tube shunts in glaucoma treatment. However, conventional viscometers are not suitable for aqueous humor due to the limited sample volume-only tens of microliters-that can be...