AIMC Topic: Middle Aged

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Unique liver function in high myopia: associations with myopic macular degeneration.

BMC ophthalmology
PURPOSE: To investigate liver function and lipid indexes in patients with high myopia and their association with myopic macular degeneration (MMD).

Accuracy is not enough: explainable boosting machine model and identification of candidate biomarkers for real-time sepsis risk assessment in the emergency department.

BMC emergency medicine
BACKGROUND: Sepsis poses a significant threat in emergency settings, necessitating tools for early and interpretable risk assessment. This study aimed to develop a robust explainable boosting machine (EBM) model, one of the explainable artificial int...

Normal twin PET: personalized generative modeling for confounder correction and anomaly detection in whole-body PET/CT.

Scientific reports
Variable physiological [F]FDG uptake patterns and a lack of labelled data make it challenging to automatically distinguish normal from pathological suspicious uptake in whole-body PET/CT imaging. We propose a deep learning method that generates patie...

Deep learning-based classification of benign and malignant breast microcalcifications in mammography.

Scientific reports
The classification of malignant versus benign microcalcifications in mammograms remains a critical yet challenging task in breast cancer screening. Deep learning models, particularly convolutional neural networks, have demonstrated promising results;...

Predictive biomarkers validation of CD3 cell apheresis yield in CAR-T manufacturing for diffuse large B-cell lymphoma: a machine learning approach.

Scientific reports
Chimeric antigen receptor (CAR) T-cell therapy has shown significant success in treating diffuse large B-cell lymphoma (DLBCL). The initial step involves collecting autologous CD3 lymphocytes through apheresis, in which obtaining an adequate CD3 cell...

Survival machine learning models for predicting all-cause and case-specific mortality risk in metabolic dysfunction-associated fatty liver disease patients.

Scientific reports
Emerging evidence links metabolic dysfunction-associated fatty liver disease (MAFLD) with increased all-cause and circulatory system disease (CSD) mortality in adults, yet survival machine learning studies are limited. This study analyzed 4415 NHANES...

Computed tomography-based nnU-Net for region-specific brain structural changes across the alzheimer's continuum and frontotemporal dementia subtypes.

Scientific reports
Quantifying structural brain changes is critical for diagnosing and monitoring neurodegenerative diseases. Although magnetic resonance imaging (MRI) is the silver standard, limited accessibility and cost hamper routine use. We developed a deep learni...

Development and validation of an interpretable predictive machine learning model for successful weaning of continuous renal replacement therapy.

Scientific reports
Continuous renal replacement therapy (CRRT) is a vital intervention for critically ill patients with severe acute kidney injury, yet no standardized criteria exist to determine the optimal time for its discontinuation. We developed and validated mach...

Machine learning classification of inflammatory bowel disease activity using white blood cell subsets.

BMJ open gastroenterology
OBJECTIVE: The lack of a rapid, validated, consistent test for tracking disease activity in patients with inflammatory bowel disease (IBD) is currently a major challenge. Currently used biomarkers have notable disadvantages, such as the slow processi...