AIMC Topic: Models, Biological

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Accelerated Brain Aging in Schizophrenia: A Longitudinal Pattern Recognition Study.

The American journal of psychiatry
OBJECTIVE: Despite the multitude of longitudinal neuroimaging studies that have been published, a basic question on the progressive brain loss in schizophrenia remains unaddressed: Does it reflect accelerated aging of the brain, or is it caused by a ...

Small-World Propensity and Weighted Brain Networks.

Scientific reports
Quantitative descriptions of network structure can provide fundamental insights into the function of interconnected complex systems. Small-world structure, diagnosed by high local clustering yet short average path length between any two nodes, promot...

Assistive Control System for Upper Limb Rehabilitation Robot.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
This paper presents an assistive control system with a special kinematic structure of an upper limb rehabilitation robot embedded with force/torque sensors. A dynamic human model integrated with sensing torque is used to simulate human interaction un...

Minimum Entropy Rate Simplification of Stochastic Processes.

IEEE transactions on pattern analysis and machine intelligence
We propose minimum entropy rate simplification (MERS), an information-theoretic, parameterization-independent framework for simplifying generative models of stochastic processes. Applications include improving model quality for sampling tasks by conc...

Enhancement of finger motion range with compliant anthropomorphic joint design.

Bioinspiration & biomimetics
Robotic researchers have been greatly inspired by the human hand in the search to design and build adaptive robotic hands. Especially, joints have received a lot of attention upon their role in maintaining the passive compliance that gives the finger...

Network stratification analysis for identifying function-specific network layers.

Molecular bioSystems
A major challenge of systems biology is to capture the rewiring of biological functions (e.g. signaling pathways) in a molecular network. To address this problem, we proposed a novel computational framework, namely network stratification analysis (Ne...

Integrative modeling of multi-omics data to identify cancer drivers and infer patient-specific gene activity.

BMC systems biology
BACKGROUND: High throughput technologies have been used to profile genes in multiple different dimensions, such as genetic variation, copy number, gene and protein expression, epigenetics, metabolomics. Computational analyses often treat these differ...

Synthetic collective intelligence.

Bio Systems
Intelligent systems have emerged in our biosphere in different contexts and achieving different levels of complexity. The requirement of communication in a social context has been in all cases a determinant. The human brain, probably co-evolving with...

Hydrodynamics of a robotic fish tail: effects of the caudal peduncle, fin ray motions and the flow speed.

Bioinspiration & biomimetics
Recent advances in understanding fish locomotion with robotic devices have included the use of biomimetic flapping based and fin undulatory locomotion based robots, treating two locomotions separately from each other. However, in most fish species, p...

Network-based in silico drug efficacy screening.

Nature communications
The increasing cost of drug development together with a significant drop in the number of new drug approvals raises the need for innovative approaches for target identification and efficacy prediction. Here, we take advantage of our increasing unders...