AIMC Topic: Multivariate Analysis

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Computer aided quantification of intratumoral stroma yields an independent prognosticator in rectal cancer.

Cellular oncology (Dordrecht, Netherlands)
PURPOSE: Tumor-stroma ratio (TSR) serves as an independent prognostic factor in colorectal cancer and other solid malignancies. The recent introduction of digital pathology in routine tissue diagnostics holds opportunities for automated TSR analysis....

Using artificial neural network and multivariate calibration methods for simultaneous spectrophotometric analysis of Emtricitabine and Tenofovir alafenamide fumarate in pharmaceutical formulation of HIV drug.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Spectrophotometric analysis method based on artificial neural network (ANN), partial least squares regression (PLS) and principal component regression (PCR) models was proposed for the simultaneous determination of Emtricitabine (ETB) and Tenofovir a...

Prediction of mortality following pediatric heart transplant using machine learning algorithms.

Pediatric transplantation
BACKGROUND: Optimizing transplant candidates' priority for donor organs depends on the accurate assessment of post-transplant outcomes. Due to the complexity of transplantation and the wide range of possible serious complications, recipient outcomes ...

A decision support tool for early detection of knee OsteoArthritis using X-ray imaging and machine learning: Data from the OsteoArthritis Initiative.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
This paper presents a fully developed computer aided diagnosis (CAD) system for early knee OsteoArthritis (OA) detection using knee X-ray imaging and machine learning algorithms. The X-ray images are first preprocessed in the Fourier domain using a c...

Defining and discriminating responders from non-responders following transurethral resection of the prostate.

Scandinavian journal of urology
BACKGROUND: Transurethral resection of the prostate (TURP) is the reference standard surgical treatment for lower urinary tract symptoms (LUTS) related to benign prostatic enlargement. The aim of this study was to investigate the response rate follow...

Association of time to colonoscopy after a positive fecal test result and fecal hemoglobin concentration with risk of advanced colorectal neoplasia.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
BACKGROUND: We evaluated the risk of advanced colorectal neoplasia (ACRN) and colorectal cancer (CRC) according to time to colonoscopy after positive fecal immunochemical test (FIT), fecal hemoglobin concentration, and combination of both.

Toward Automatic Risk Assessment to Support Suicide Prevention.

Crisis
Suicide has been considered an important public health issue for years and is one of the main causes of death worldwide. Despite prevention strategies being applied, the rate of suicide has not changed substantially over the past decades. Suicide ri...

A coupled multivariate statistics, geostatistical and machine-learning approach to address soil pollution in a prototypical Hg-mining site in a natural reserve.

Chemosphere
The impact of mining activities on the environment is vast. In this regard, many mines were operating well before the introduction of environmental law. This is particularly true of cinnabar mines, whose activity has declined for decades due to growi...

Machine Learning Reveals Protein Signatures in CSF and Plasma Fluids of Clinical Value for ALS.

Scientific reports
We use shotgun proteomics to identify biomarkers of diagnostic and prognostic value in individuals diagnosed with amyotrophic lateral sclerosis. Matched cerebrospinal and plasma fluids were subjected to abundant protein depletion and analyzed by nano...

Individualized prediction of dispositional worry using white matter connectivity.

Psychological medicine
BACKGROUND: Excessive worry is a defining feature of generalized anxiety disorder and is present in a wide range of other psychiatric conditions. Therefore, individualized predictions of worry propensity could be highly relevant in clinical practice,...