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Neoplasm Grading

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A novel assessment of whole-mount Gleason grading in prostate cancer to identify candidates for radical prostatectomy: a machine learning-based multiomics study.

Theranostics
: This study aims to assess whole-mount Gleason grading (GG) in prostate cancer (PCa) accurately using a multiomics machine learning (ML) model and to compare its performance with biopsy-proven GG (bxGG) assessment. : A total of 146 patients with PCa...

Utilizing machine learning to tailor radiotherapy and chemoradiotherapy for low-grade glioma patients.

PloS one
BACKGROUND: There is ongoing uncertainty about the effectiveness of various adjuvant treatments for low-grade gliomas (LGGs). Machine learning (ML) models that predict individual treatment effects (ITE) and provide treatment recommendations could hel...

Accurate low and high grade glioma classification using free water eliminated diffusion tensor metrics and ensemble machine learning.

Scientific reports
Glioma, a predominant type of brain tumor, can be fatal. This necessitates an early diagnosis and effective treatment strategies. Current diagnosis is based on biopsy, prompting the need for non invasive neuroimaging alternatives. Diffusion tensor im...

Metabolic signatures derived from whole-brain MR-spectroscopy identify early tumor progression in high-grade gliomas using machine learning.

Journal of neuro-oncology
PURPOSE: Recurrence for high-grade gliomas is inevitable despite maximal safe resection and adjuvant chemoradiation, and current imaging techniques fall short in predicting future progression. However, we introduce a novel whole-brain magnetic resona...

Sexually dimorphic computational histopathological signatures prognostic of overall survival in high-grade gliomas via deep learning.

Science advances
High-grade glioma (HGG) is an aggressive brain tumor. Sex is an important factor that differentially affects survival outcomes in HGG. We used an end-to-end deep learning approach on hematoxylin and eosin (H&E) scans to (i) identify sex-specific hist...

Assessing the Performance of Deep Learning for Automated Gleason Grading in Prostate Cancer.

Studies in health technology and informatics
Prostate cancer is a dominant health concern calling for advanced diagnostic tools. Utilizing digital pathology and artificial intelligence, this study explores the potential of 11 deep neural network architectures for automated Gleason grading in pr...

Artificial intelligence and advanced MRI techniques: A comprehensive analysis of diffuse gliomas.

Journal of medical imaging and radiation sciences
INTRODUCTION: The complexity of diffuse gliomas relies on advanced imaging techniques like MRI to understand their heterogeneity. Utilizing the UCSF-PDGM dataset, this study harnesses MRI techniques, radiomics, and AI to analyze diffuse gliomas for o...

Comparison of Pathologist and Artificial Intelligence-based Grading for Prediction of Metastatic Outcomes After Radical Prostatectomy.

European urology oncology
Gleason grade group (GG) is the most powerful prognostic variable in localized prostate cancer; however, interobserver variability remains a challenge. Artificial intelligence algorithms applied to histopathologic images standardize grading, but most...

Prostate cancer treatment recommendation study based on machine learning and SHAP interpreter.

Cancer science
This study utilized data from 140,294 prostate cancer cases from the Surveillance, Epidemiology, and End Results (SEER) database. Here, 10 different machine learning algorithms were applied to develop treatment options for predicting patients with pr...

Multimodal deep learning improves recurrence risk prediction in pediatric low-grade gliomas.

Neuro-oncology
BACKGROUND: Postoperative recurrence risk for pediatric low-grade gliomas (pLGGs) is challenging to predict by conventional clinical, radiographic, and genomic factors. We investigated if deep learning (DL) of magnetic resonance imaging (MRI) tumor f...