We introduce the CDRP (Concatenated Diagnostic-Relapse Prognostic) architecture for multi-task deep learning that incorporates a clinical algorithm, e.g., a risk stratification schema to improve prognostic profiling. We present the first application ...
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Nov 1, 2018
BACKGROUND AND PURPOSE: Recurrence is the main risk for high-grade serous ovarian cancer (HGSOC) and few prognostic biomarkers were reported. In this study, we proposed a novel deep learning (DL) method to extract prognostic biomarkers from preoperat...
Journal of the American Society of Cytopathology
Aug 28, 2018
INTRODUCTION: Locoregional recurrence of thyroid carcinoma has a negative impact on patient prognosis. In the current study, we retrospectively reviewed cases of thyroid bed lesions in the last 3 years, correlating cytologic diagnoses with clinical f...
Journal of magnetic resonance imaging : JMRI
Aug 21, 2018
BACKGROUND: Oncotype Dx is a validated genetic analysis that provides a recurrence score (RS) to quantitatively predict outcomes in patients who meet the criteria of estrogen receptor positive / human epidermal growth factor receptor-2 negative (ER+/...
Gene expression data using retrieved ovarian cancer (OC) samples were used to identify genes of interest and a support vector machine (SVM) classifier was subsequently established to predict the recurrence of OC. Three datasets (GSE17260, GSE44104 an...
Computational and mathematical methods in medicine
Jun 13, 2018
Glioma constitutes the most common type of primary brain tumor with a dismal survival, often measured in terms of months or years. The thin line between treatment effectiveness and patient harm underpins the importance of tailoring clinical managemen...
Data from an experienced center that randomized patients to open vs robotic cystectomy for urothelial cancer demonstrated locational differences in recurrence. While the study was not powered to detect survival differences, overall, cancer-specific, ...
Journal of the American College of Radiology : JACR
May 19, 2018
PURPOSE: The aim of this study was to use machine learning to predict abdominal recurrence on CT on the basis of serial cancer antigen 125 (CA125) levels in patients with advanced high-grade serous ovarian cancer on surveillance.
OBJECTIVE: Accumulating evidence support that complete cytoreduction (CC) at the time of secondary cytoreductive surgery (SCS) improves survival in patients affected by recurrent ovarian cancer (ROC). Here, we aimed to determine whether artificial in...
Journal of cancer research and clinical oncology
Feb 9, 2018
PURPOSE: To determine whether multivariate machine learning models of algorithmically assessed magnetic resonance imaging (MRI) features from breast cancer patients are associated with Oncotype DX (ODX) test recurrence scores.
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