AIMC Topic: Neurodegenerative Diseases
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Integrative machine learning and molecular simulation approaches identify GSK3β inhibitors for neurodegenerative disease therapy.
Scientific reports
Jul 1, 2025
Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), are a growing global health concern, especially among the elderly, posing significant challenges to well-being and survival. GSK3β, a serine/threonine...
Ultradeep N-glycoproteome atlas of mouse reveals spatiotemporal signatures of brain aging and neurodegenerative diseases.
Nature communications
Jul 1, 2025
The current depth of site-specific N-glycoproteomics is insufficient to fully characterize glycosylation events in biological samples. Herein, we achieve an ultradeep and precision analysis of the N-glycoproteome of mouse tissues by integrating multi...
An FDG-PET-Based Machine Learning Framework to Support Neurologic Decision-Making in Alzheimer Disease and Related Disorders.
Neurology
Jun 27, 2025
BACKGROUND AND OBJECTIVES: Distinguishing neurodegenerative diseases is a challenging task requiring neurologic expertise. Clinical decision support systems (CDSSs) powered by machine learning (ML) and artificial intelligence can assist with complex ...
Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration.
Journal of neurology
Jun 25, 2025
INTRODUCTION: Recent research has suggested that neuroinflammation may be important in the pathogenesis of neurodegenerative diseases. Free-water diffusion (FWD) has been proposed as a non-invasive neuroimaging-based biomarker for neuroinflammation.
Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury.
Signal transduction and targeted therapy
Jun 23, 2025
Traumatic brain injury (TBI) is a major public health concern associated with an increased risk of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and chronic traumatic encephalopathy, yet the underlying molec...
EEG-based neurodegenerative disease diagnosis: comparative analysis of conventional methods and deep learning models.
Scientific reports
May 7, 2025
In the context of lifestyle changes, stress and other environmental factors have resulted in the sudden hike in dementia globally. This necessitates investigations with respect to every horizon of the due cause for it; further on, the diagnosis and t...
Enhancing Neurodegenerative Disease Diagnosis Through Confidence-Driven Dynamic Spatio-Temporal Convolutional Network.
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
May 7, 2025
Dynamic brain networks are more effective than static networks in characterizing the evolving patterns of brain functional connectivity, making them a more promising tool for diagnosing neurodegenerative diseases. However, existing classification met...
Therapeutic potential of enzymes, neurosteroids, and synthetic steroids in neurodegenerative disorders: A critical review.
The Journal of steroid biochemistry and molecular biology
Apr 25, 2025
Neurodegenerative disorders present a significant challenge to healthcare systems, mainly due to the limited availability of effective treatment options to halt or reverse disease progression. Endogenous steroids synthesized in the central nervous sy...
Radiomics across modalities: a comprehensive review of neurodegenerative diseases.
Clinical radiology
Apr 3, 2025
Radiomics allows extraction from medical images of quantitative features that are able to reveal tissue patterns that are generally invisible to human observers. Despite the challenges in visually interpreting radiomic features and the computational ...
Transforming neurodegenerative disorder care with machine learning: Strategies and applications.
Neuroscience
Mar 20, 2025
Neurodegenerative diseases (NDs), characterized by progressive neuronal degeneration and manifesting in diverse forms such as memory loss and movement disorders, pose significant challenges due to their complex molecular mechanisms and heterogeneous ...
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