AIMC Topic: NF-kappa B

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[Consensus ensemble neural network multitarget model of RAGE inhibitory activity of chemical compounds].

Biomeditsinskaia khimiia May 1, 2021
RAGE signal transduction via the RAGE-NF-κB signaling pathway is one of the mechanisms of inflammatory reactions that cause severe complications in diabetes mellitus. RAGE inhibitors are promising pharmacological compounds that require the developmen...
Molecular Docking Simulation Consensus Signal Transduction NF-kappa B Neural Networks, Computer
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[Neural network modeling of multitarget RAGE inhibitory activity].

Biomeditsinskaia khimiia Feb 1, 2019
Based on the methodology of artificial neural networks, models describing the dependence of the level of RAGE inhibitory activity on the affinity of compounds for target proteins of the RAGE-NF-kB signal pathway have been costructed. A validated data...
Humans Neural Networks, Computer Molecular Docking Simulation Signal Transduction NF-kappa B Receptor for Advanced Glycation End Products
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[Effects of ATP on expression of inflammatory factors in endothelial progenitor cells induced by LPS and the mechanisms].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences Dec 28, 2018
To investigate the effects of adenosine triphosphate (ATP) on expression of inflammatory factors induced by lipopolysaccharide (LPS) in endothelial progenitor cells (EPCs), and to elucidate the possible mechanisms.
 Methods: Mononuclear cells were is...
Myeloid Differentiation Factor 88 Humans Toll-Like Receptor 4 Leukocytes, Mononuclear Endothelial Progenitor Cells Signal Transduction NF-kappa B Lipopolysaccharides Adenosine Triphosphate Gene Expression Regulation Lipopolysaccharide Receptors
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Effect of simvastatin on the SIRT2/NF-κB pathway in rats with acute pulmonary embolism.

Pharmaceutical biology Dec 1, 2018
CONTEXT: Statins have been widely used in acute pulmonary embolism (APE), while simvastatin has been well-established for the prevention of pulmonary hypertension, which was supposed to be an attractive recommendation for APE treatment.
Pulmonary Embolism Signal Transduction Animals Sirtuin 2 Treatment Outcome Hydroxymethylglutaryl-CoA Reductase Inhibitors Male Rats, Sprague-Dawley Simvastatin Rats NF-kappa B
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[Effect of TNF-α on the ability of stem cells from human exfoliated deciduous teeth to promote osteoclastogenesis].

Shanghai kou qiang yi xue = Shanghai journal of stomatology Oct 1, 2018
PURPOSE: To investigate the effect of tumor necrosis factor-α (TNF-α) on the ability of stem cells from human exfoliated deciduous teeth (SHED) to promote osteoclastogenesis.
Osteogenesis Tooth, Deciduous Leukocytes, Mononuclear Stem Cells Humans NF-kappa B Tumor Necrosis Factor-alpha Cells, Cultured
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[MiR-142-3p inhibits lipopolysaccharide-induced inflammatory response in human periodontal ligament cells through targeting IRAK1].

Shanghai kou qiang yi xue = Shanghai journal of stomatology Dec 1, 2016
PURPOSE: To investigate the effects of miR-142-3p overexpression on secretion of inflammatory factors in human periodontal ligament cells (hPDLCs) induced by lipopolysaccharide (LPS) and its underlying mechanism.
Lipopolysaccharides Cell Line MicroRNAs NF-kappa B Periodontal Ligament Transfection Interleukin-1 Receptor-Associated Kinases Tumor Necrosis Factor-alpha Humans Interleukin-6 Inflammation Signal Transduction
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Metformin Alleviates Lipopolysaccharide-induced Acute Lung Injury through Suppressing Toll-like Receptor 4 Signaling.

Iranian journal of allergy, asthma, and immunology Dec 1, 2016
Signaling AMP-activated protein kinase (AMPK), an energy sensing enzyme, has been implicated in controlling inflammation. In this study we investigated whether activation of AMPK by metformin could protect the lung from lipopolysaccharide (LPS)-induc...
Rats Toll-Like Receptor 4 Hypoglycemic Agents Peroxidase Lipopolysaccharides Acute Lung Injury Blotting, Western Lung Tumor Necrosis Factor-alpha NF-kappa B Animals Real-Time Polymerase Chain Reaction AMP-Activated Protein Kinases Male RNA, Messenger Metformin Rats, Wistar Myeloid Differentiation Factor 88
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Tashinone II A-sulfoacid-natrum elevates the pain threshold through inhibiting nuclear factor kappa B pathway in neuropathic cancer pain.

Indian journal of cancer Dec 1, 2015
OBJECTIVE: The purpose of this study was to evaluate the effects of Tashinone II A-sulfoacid-natrum on the pain threshold and potential molecular mechanism for neuropathic cancer pain.
NF-kappa B Sciatic Nerve Sulfuric Acid Esters Neuralgia Pain Threshold Abietanes Cancer Pain Animals Male Mice Mice, Inbred BALB C
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[Qinghuachang Decoction Inhibited NF-kappaB Activation in LPS-induced Human Enterocytes].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine Nov 1, 2015
OBJECTIVE: To explore anti-inflammation and mechanism of Qinghuachang Decoction (QD) by using LPS stimulated differentiated colon cancer Caco-2 cells (as an inflammation model of human enterocytes).
I-kappa B Proteins NF-kappa B NF-KappaB Inhibitor alpha Enterocytes Colon Caco-2 Cells Humans Inflammation Phosphorylation Tumor Necrosis Factor-alpha Lipopolysaccharides Interleukin-8 Drugs, Chinese Herbal
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[Role and mechanism of the NOD-like receptor 3 inflammasome in ventilator-induced lung injury in rats].

Zhonghua wei zhong bing ji jiu yi xue Oct 1, 2015
OBJECTIVE: To investigate the role and its mechanism of the NOD-like receptor 3 (NLRP3) inflammasome in alveolar macrophages in ventilator-induced lung injury (VILI) in rats.
Lung RNA, Messenger Rats Rats, Sprague-Dawley Animals Male Respiration, Artificial NF-kappa B NLR Family, Pyrin Domain-Containing 3 Protein Interleukin-18 Inflammasomes Carrier Proteins Tidal Volume Interleukin-1beta Random Allocation Macrophages, Alveolar Bronchoalveolar Lavage Fluid Ventilator-Induced Lung Injury Caspase 1
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