AIMC Topic: Papillomavirus Infections

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Spatial profiling of HPV-stratified head and neck squamous cell carcinoma reveals distinct immune niches and microenvironmental architectures.

Journal of translational medicine
BACKGROUND: HPV status is a key determinant of prognosis and treatment response in head and neck squamous cell carcinoma (HNSCC). To investigate how HPV influences the tumor-immune-stromal landscape, we performed high-dimensional spatial profiling, i...

Explainable AI based cervical cancer prediction using FSAE feature engineering and H2O AutoML.

Scientific reports
Cervical cancer, predominantly caused by Human Papillomavirus (HPV) infection, remains a significant global health burden for women, contributing to elevated morbidity and mortality rates. Early and accurate prediction is critical in improving patien...

AI-assisted cervical cytology precancerous screening for high-risk population in resource-limited regions using a compact microscope.

Nature communications
Insufficient coverage of cervical cytology screening in resource-limited areas remains a major bottleneck for women's health, as traditional centralized methods require significant investment and many qualified pathologists. Using consumer-grade elec...

Network-based approach identifies key genes associated with tumor heterogeneity in HPV positive and negative head and neck cancer patients.

Scientific reports
Head and Neck Squamous Cell Carcinoma (HNSCC) is the seventh most prevalent cancer worldwide and is classified as human papillomavirus (HPV) positive or negative. Substantial heterogeneity has been observed in the two groups, posing a significant cli...

Accuracy and acceptability of self-sampling HPV testing in cervical cancer screening: a population-based study in rural Yunnan, China.

Scientific reports
To evaluate the accuracy and acceptability of self-sampling samples for HPV testing for cervical cancer screening in rural Yunnan of China. In 2022, 3000 women aged 17-69 were recruited and provided self-sampling vaginal samples alongside provider-sa...

Challenges and Opportunities for Global Cervical Cancer Elimination: How Can We Build a Model for Other Cancers?

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
Cervical cancer remains a leading cause of cancer-related death among women globally, despite the availability of effective prevention through human papillomavirus (HPV) vaccination and HPV-based screening. This review explores the state-of-the-art t...

Post-processing steps improve generalisability and robustness of an MRI-based radiogenomic model for human papillomavirus status prediction in oropharyngeal cancer.

European radiology
OBJECTIVES: To assess the impact of image post-processing steps on the generalisability of MRI-based radiogenomic models. Using a human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma (OPSCC) prediction model, this study examines...

Molecular detection of hrHPV-induced high-grade squamous intraepithelial lesions of the cervix through a targeted RNA next generation sequencing assay.

Molecular medicine (Cambridge, Mass.)
BACKGROUND: Cervical cancer screening programs are increasingly relying on sensitive molecular approaches as primary tests to detect high-risk human papillomaviruses (hrHPV), the causative agents of cervix cancer. Although hrHPV infection is a pre-re...

Advancements in fluorescent nanobiosensors for HPV detection: from integrating nanomaterials to DNA nanotechnology.

International journal of biological macromolecules
Human papillomavirus (HPV) is a leading cause of cervical cancer and other malignancies, necessitating the development of highly sensitive and specific detection tools. This review explores recent advancements in fluorescent nanobiosensors (FNBS) for...