AIMC Topic: Parkinson Disease

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Closed-Loop Modulation of the Pathological Disorders of the Basal Ganglia Network.

IEEE transactions on neural networks and learning systems
A generalized predictive closed-loop control strategy to improve the basal ganglia activity patterns in Parkinson's disease (PD) is explored in this paper. Based on system identification, an input-output model is established to reveal the relationshi...

Diagnosing Parkinson's Diseases Using Fuzzy Neural System.

Computational and mathematical methods in medicine
This study presents the design of the recognition system that will discriminate between healthy people and people with Parkinson's disease. A diagnosing of Parkinson's diseases is performed using fusion of the fuzzy system and neural networks. The st...

Computer-Aided Diagnosis of Parkinson's Disease Using Enhanced Probabilistic Neural Network.

Journal of medical systems
Early and accurate diagnosis of Parkinson's disease (PD) remains challenging. Neuropathological studies using brain bank specimens have estimated that a large percentages of clinical diagnoses of PD may be incorrect especially in the early stages. In...

PDON: Parkinson's disease ontology for representation and modeling of the Parkinson's disease knowledge domain.

Theoretical biology & medical modelling
BACKGROUND: Despite the unprecedented and increasing amount of data, relatively little progress has been made in molecular characterization of mechanisms underlying Parkinson's disease. In the area of Parkinson's research, there is a pressing need to...

A Method for Automatic and Objective Scoring of Bradykinesia Using Orientation Sensors and Classification Algorithms.

IEEE transactions on bio-medical engineering
Correct assessment of bradykinesia is a key element in the diagnosis and monitoring of Parkinson's disease. Its evaluation is based on a careful assessment of symptoms and it is quantified using rating scales, where the Movement Disorders Society-Spo...

A Fuzzy Inference System for Closed-Loop Deep Brain Stimulation in Parkinson's Disease.

Journal of medical systems
Parkinsons disease is a complex neurodegenerative disorder for which patients present many symptoms, tremor being the main one. In advanced stages of the disease, Deep Brain Stimulation is a generalized therapy which can significantly improve the mot...

Machine learning classification of medication adherence in patients with movement disorders using non-wearable sensors.

Computers in biology and medicine
Medication non-adherence is a major concern in the healthcare industry and has led to increases in health risks and medical costs. For many neurological diseases, adherence to medication regimens can be assessed by observing movement patterns. Howeve...

Unsupervised learning based feature extraction for differential diagnosis of neurodegenerative diseases: A case study on early-stage diagnosis of Parkinson disease.

Journal of neuroscience methods
BACKGROUND: The development of MRI based methods could prove extremely valuable for identification of reliable biomarkers to aid diagnosis of neurodegenerative diseases (NDs). A great deal of current research has been aimed at identification biomarke...

Cost-efficient FPGA implementation of basal ganglia and their Parkinsonian analysis.

Neural networks : the official journal of the International Neural Network Society
The basal ganglia (BG) comprise multiple subcortical nuclei, which are responsible for cognition and other functions. Developing a brain-machine interface (BMI) demands a suitable solution for the real-time implementation of a portable BG. In this st...