AIMC Topic: Phenotype
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Phenotypic antibiotic resistance prediction using antibiotic resistance genes and machine learning models in Mannheimia haemolytica.
Veterinary microbiology
Jan 8, 2025
Mannheimia haemolytica is one of the most common causative agents of bovine respiratory disease (BRD); however, antibiotic resistance in this species is increasing, making treatment more difficult. Integrative-conjugative elements (ICE), a subset of ...
Machine learning derivation of two cardiac arrest subphenotypes with distinct responses to treatment.
Journal of translational medicine
Jan 6, 2025
INTRODUCTION: Cardiac arrest (CA), characterized by its heterogeneity, poses challenges in patient management. This study aimed to identify clinical subphenotypes in CA patients to aid in patient classification, prognosis assessment, and treatment de...
Segmentation aware probabilistic phenotyping of single-cell spatial protein expression data.
Nature communications
Jan 4, 2025
Spatial protein expression technologies can map cellular content and organization by simultaneously quantifying the expression of >40 proteins at subcellular resolution within intact tissue sections and cell lines. However, necessary image segmentati...
Rapid and accurate multi-phenotype imputation for millions of individuals.
Nature communications
Jan 4, 2025
Deep phenotyping can enhance the power of genetic analysis, including genome-wide association studies (GWAS), but the occurrence of missing phenotypes compromises the potential of such resources. Although many phenotypic imputation methods have been ...
Leveraging Transformers-based models and linked data for deep phenotyping in radiology.
Computer methods and programs in biomedicine
Jan 3, 2025
BACKGROUND AND OBJECTIVE: Despite significant investments in the normalization and the standardization of Electronic Health Records (EHRs), free text is still the rule rather than the exception in clinical notes. The use of free text has implications...
A Systematic Approach to Prioritise Diagnostically Useful Findings for Inclusion in Electronic Health Records as Discrete Data to Improve Clinical Artificial Intelligence Tools and Genomic Research.
Clinical oncology (Royal College of Radiologists (Great Britain))
Dec 28, 2024
AIMS: The recent widespread use of electronic health records (EHRs) has opened the possibility for innumerable artificial intelligence (AI) tools to aid in genomics, phenomics, and other research, as well as disease prevention, diagnosis, and therapy...
Digital phenotyping from heart rate dynamics: Identification of zero-poles models with data-driven evolutionary learning.
Computers in biology and medicine
Dec 27, 2024
Heart rate response to physical activity is widely investigated in clinical and training practice, as it provides information on a person's physical state. For emerging digital phenotyping approaches, there is a need for individualized model estimati...
Phenotype prediction in plants is improved by integrating large-scale transcriptomic datasets.
NAR genomics and bioinformatics
Dec 27, 2024
Research on the dynamic expression of genes in plants is important for understanding different biological processes. We used the large amounts of transcriptomic data from various plant sample sources that are publicly available to investigate whether...
Hypothesis generation for rare and undiagnosed diseases through clustering and classifying time-versioned biological ontologies.
PloS one
Dec 26, 2024
Rare diseases affect 1-in-10 people in the United States and despite increased genetic testing, up to half never receive a diagnosis. Even when using advanced genome sequencing platforms to discover variants, if there is no connection between the var...
An integrated microflow cytometry platform with artificial intelligence capabilities for point-of-care cellular phenotype analysis.
Biosensors & bioelectronics
Dec 23, 2024
The EZ DEVICE is an integrated fluorescence microflow cytometer designed for automated cell phenotyping and enumeration using artificial intelligence (AI). The platform consists of a laser diode, optical filter, objective lens, CMOS image sensor, and...
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