Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Jan 1, 2023
In life science and medicine, we have been conducting research using laboratory animals such as mice, rats and monkeys. However, it is impossible for humans to fully understand the feelings and conditions of experimental animals with whom we cannot c...
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Apr 25, 2022
Physiological studies reveal that rats rely on multiple spatial cells for spatial navigation and memory. In this paper, we investigated the firing mechanism of spatial cells within the entorhinal-hippocampal structure of the rat brain and proposed a ...
Toxicological sciences : an official journal of the Society of Toxicology
Mar 28, 2022
Animal studies are a critical component in biomedical research, pharmaceutical product development, and regulatory submissions. There is a worldwide effort in toxicology toward "reducing, refining, and replacing" animal use. Here, we proposed a deep ...
BACKGROUND: Sauromatum guttatum (S. guttatum) is used in the treatment of blood disorders and reportedly has a spasmolytic activity through Ca2+ channel inhibition.
Shanghai kou qiang yi xue = Shanghai journal of stomatology
Dec 1, 2021
PURPOSE: To explore the influence of naringenin on osteogenic differentiation of bone mesenchymal stem cells(BMSCs), and the role of SDF-1α/CXCR4 signaling axis in the osteogenic differentiation by naringenin.
Toxicological sciences : an official journal of the Society of Toxicology
Aug 3, 2021
Detection of seizures as well as that of seizure auras is effective in improving the predictive accuracy of seizure liability of drugs. Whereas electroencephalography has been known to be effective for the detection of seizure liability, no establish...
High-precision delivery of microrobots at the whole-body scale is of considerable importance for efforts toward targeted therapeutic intervention. However, vision-based control of microrobots, to deep and narrow spaces inside the body, remains a chal...
Cerebral cortex (New York, N.Y. : 1991)
Mar 5, 2021
During the execution of working memory tasks, task-relevant information is processed by local circuits across multiple brain regions. How this multiarea computation is conducted by the brain remains largely unknown. To explore such mechanisms in spat...
The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The n...
Gene regulatory elements, including promoters, enhancers, silencers, etc., control transcriptional programs in a spatiotemporal manner. Though these elements are known to be able to induce either positive or negative transcriptional control, the comm...
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