AIMC Topic: Reproducibility of Results

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Experimental validation of robot-assisted cardiovascular catheterization: model-based versus model-free control.

International journal of computer assisted radiology and surgery
PURPOSE: In cardiac electrophysiology, a long and flexible catheter is delivered to a cardiac chamber for the treatment of arrhythmias. Although several robot-assisted platforms have been commercialized, the disorientation in tele-operation is still ...

Dengue forecasting in São Paulo city with generalized additive models, artificial neural networks and seasonal autoregressive integrated moving average models.

PloS one
Globally, the number of dengue cases has been on the increase since 1990 and this trend has also been found in Brazil and its most populated city-São Paulo. Surveillance systems based on predictions allow for timely decision making processes, and in ...

Abnormal brain structure as a potential biomarker for venous erectile dysfunction: evidence from multimodal MRI and machine learning.

European radiology
OBJECTIVES: To investigate the cerebral structural changes related to venous erectile dysfunction (VED) and the relationship of these changes to clinical symptoms and disorder duration and distinguish patients with VED from healthy controls using a m...

Interpretation of biological experiments changes with evolution of the Gene Ontology and its annotations.

Scientific reports
Gene Ontology (GO) enrichment analysis is ubiquitously used for interpreting high throughput molecular data and generating hypotheses about underlying biological phenomena of experiments. However, the two building blocks of this analysis - the ontolo...

Automated ICD-9 Coding via A Deep Learning Approach.

IEEE/ACM transactions on computational biology and bioinformatics
ICD-9 (the Ninth Revision of International Classification of Diseases) is widely used to describe a patient's diagnosis. Accurate automated ICD-9 coding is important because manual coding is expensive, time-consuming, and inefficient. Inspired by the...

Detection of Pathological Voice Using Cepstrum Vectors: A Deep Learning Approach.

Journal of voice : official journal of the Voice Foundation
OBJECTIVES: Computerized detection of voice disorders has attracted considerable academic and clinical interest in the hope of providing an effective screening method for voice diseases before endoscopic confirmation. This study proposes a deep-learn...

ANTENNA, a Multi-Rank, Multi-Layered Recommender System for Inferring Reliable Drug-Gene-Disease Associations: Repurposing Diazoxide as a Targeted Anti-Cancer Therapy.

IEEE/ACM transactions on computational biology and bioinformatics
Existing drug discovery processes follow a reductionist model of "one-drug-one-gene-one-disease," which is inadequate to tackle complex diseases involving multiple malfunctioned genes. The availability of big omics data offers opportunities to transf...

Computational Prediction of Sigma-54 Promoters in Bacterial Genomes by Integrating Motif Finding and Machine Learning Strategies.

IEEE/ACM transactions on computational biology and bioinformatics
Sigma factor, as a unit of RNA polymerase holoenzyme, is a critical factor in the process of gene transcriptional regulation. It recognizes the specific DNA sites and brings the core enzyme of RNA polymerase to the upstream regions of target genes. T...

Using machine learning and quantum chemistry descriptors to predict the toxicity of ionic liquids.

Journal of hazardous materials
Large-scale application of ionic liquids (ILs) hinges on the advancement of designable and eco-friendly nature. Research of the potential toxicity of ILs towards different organisms and trophic levels is insufficient. Quantitative structure-activity ...