N -methyladenosine (m A), the most prevalent internal modification in eukaryotic RNAs, has emerged as a focal point of intensive research in recent years owing to its pivotal regulatory roles in carcinogenesis, progression, and metastasis. However, c...
Existing research indicates that bicalutamide and zoladex show significant potential in treating prostate cancer. However, in the clinical application of treating benign prostatic hyperplasia (BPH), it is limited due to relatively severe side effects...
We develop GeneRAIN, a suite of Transformer-based models that learn gene expression relationships from 410 K human bulk RNA-seq samples. Featuring a novel Binning-By-Gene normalization technique, our models capture diverse biological information beyo...
Heydari et al. present an intriguing study examining the role of three long non-coding RNAs (lncRNAs)-H19, taurine upregulated gene 1 (TUG1), and colorectal neoplasia differentially expressed (CRNDE)-in the context of Coronavirus Disease 2019 (COVID-...
Biochemical and biophysical research communications
Aug 24, 2025
Accurate prediction of long non-coding RNA (LncRNA) subcellular localization is crucial for understanding its biological functions. In this study, we proposed a novel deep learning framework, LncMamba, which utilizes a two-layer FPN network for multi...
Postmenopausal osteoporosis (PMOP) increases the risk of periodontitis (PD), yet the shared mechanisms remain unclear. Rho-signal transduction genes may play a role due to their involvement in bone remodeling. This study aimed to explore Rho-related ...
BACKGROUND: Prognostic tools for determining patients with indolent breast cancers (BCs) are far from optimal, leading to extensive overtreatment. Several studies have demonstrated mRNAs, lncRNAs and miRNAs to have prognostic potential in BC. Because...
This study developed an immune-related long non-coding RNAs (lncRNAs)-based prognostic signature by integrating multi-omics data and machine learning algorithms to predict survival and therapeutic responses in breast cancer patients. Utilizing transc...
Knee osteoarthritis (KOA) is a prevalent degenerative joint disorder, yet its underlying molecular mechanisms remain puzzling. This study aimed to uncover the genes with a causal relationship to KOA using Mendelian randomization (MR), transcriptomic ...
Despite improvements, prognosis in osteosarcoma patients remains poor, making it essential to identify additional and more robust therapeutic targets. Non-apoptotic receptor-mediated cell death (RCD), which plays a crucial role in the pathogenesis of...
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