AIMC Topic: RNA, Small Interfering

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iPiDi-PUL: identifying Piwi-interacting RNA-disease associations based on positive unlabeled learning.

Briefings in bioinformatics May 20, 2021
Accumulated researches have revealed that Piwi-interacting RNAs (piRNAs) are regulating the development of germ and stem cells, and they are closely associated with the progression of many diseases. As the number of the detected piRNAs is increasing ...
Machine Learning Algorithms Humans Principal Component Analysis RNA, Small Interfering Datasets as Topic Genetic Predisposition to Disease Computational Biology
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PVsiRNAPred: Prediction of plant exclusive virus-derived small interfering RNAs by deep convolutional neural network.

Journal of bioinformatics and computational biology Dec 1, 2019
Plant exclusive virus-derived small interfering RNAs (vsiRNAs) regulate various biological processes, especially important in antiviral immunity. The identification of plant vsiRNAs is important for understanding the biogenesis and function mechanism...
ROC Curve Plants Neural Networks, Computer Host-Pathogen Interactions Databases, Genetic Computational Biology Algorithms Plant Viruses RNA, Small Interfering
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[Down-regulated PTTG1 expression promotes the senescence of human prostate cancer LNCaP-AI].

Zhonghua nan ke xue = National journal of andrology Mar 1, 2019
OBJECTIVE: To investigate the effect of the down-regulated expression of pituitary tumor-transforming gene 1 (PTTG1) on the senescence of human castration-resistant prostate cancer LNCaP-AI cells.
RNA, Small Interfering Cell Line, Tumor Humans Securin Cell Proliferation Male beta-Galactosidase Prostatic Neoplasms, Castration-Resistant
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[Downregulation of PTTG1 expression inhibits the proliferation and invasiveness and promotes the apoptosis of human prostate cancer LNCaP-AI cells].

Zhonghua nan ke xue = National journal of andrology Jul 1, 2017
OBJECTIVE: To investigate the effects of down-regulation of PTTG1 expression on the proliferation, invasiveness and apoptosis of androgen-independent human prostate cancer LNCaP-AI cells and their sensitivity to androgen antagonists.
Cell Proliferation Apoptosis Prostatic Neoplasms Time Factors Securin Androgen Antagonists RNA, Small Interfering Humans Down-Regulation Neoplasm Invasiveness Cell Line, Tumor Transfection Male
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A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Barrier and Selectively Delivering siRNA to Neurons for Alzheimer's Disease Treatment.

Current pharmaceutical biotechnology Jan 1, 2017
BACKGROUND: Alzheimer's disease (AD) is one of most serious threats to human beings, however, the treatment is hindered by blood-brain barrier and poor intra-brain cell selectivity.
Gene Knockdown Techniques Molecular Targeted Therapy PC12 Cells Neurons Alzheimer Disease Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases Permeability Drug Carriers RNA, Small Interfering Humans Rats Blood-Brain Barrier Mice, Nude Animals Nanoparticles Drug Delivery Systems
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Rapamycin inhibits transforming growth factor beta 1 induced myofibroblast differentiation via the phosphorylated-phosphatidylinositol 3-kinase mammalian target of rapamycin signal pathways in nasal polyp-derived fibroblasts.

American journal of rhinology & allergy Nov 1, 2016
PURPOSE: Rapamycin has antiproliferative and antifibrogenic effects in vitro and in vivo. The purpose of this study was to evaluate the effects of rapamycin on transforming growth factor (TGF) beta 1 induced myofibroblast differentiation (alpha smoot...
Humans Fibroblasts Immunosuppressive Agents Myofibroblasts Cells, Cultured Signal Transduction Sirolimus RNA, Small Interfering Transforming Growth Factor beta Collagen Actins TOR Serine-Threonine Kinases Phosphatidylinositol 3-Kinase Extracellular Matrix Nasal Polyps Cell Differentiation
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