AIMC Topic: RNA, Small Interfering

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[Downregulation of PTTG1 expression inhibits the proliferation and invasiveness and promotes the apoptosis of human prostate cancer LNCaP-AI cells].

Zhonghua nan ke xue = National journal of andrology Jul 1, 2017
OBJECTIVE: To investigate the effects of down-regulation of PTTG1 expression on the proliferation, invasiveness and apoptosis of androgen-independent human prostate cancer LNCaP-AI cells and their sensitivity to androgen antagonists.
Humans Male Time Factors Cell Line, Tumor Cell Proliferation Apoptosis Neoplasm Invasiveness Prostatic Neoplasms Androgen Antagonists RNA, Small Interfering Transfection Securin Down-Regulation
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A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Barrier and Selectively Delivering siRNA to Neurons for Alzheimer's Disease Treatment.

Current pharmaceutical biotechnology Jan 1, 2017
BACKGROUND: Alzheimer's disease (AD) is one of most serious threats to human beings, however, the treatment is hindered by blood-brain barrier and poor intra-brain cell selectivity.
Humans Blood-Brain Barrier Drug Delivery Systems Animals Nanoparticles Rats Mice, Nude Drug Carriers RNA, Small Interfering Neurons Alzheimer Disease Permeability Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases Molecular Targeted Therapy PC12 Cells Gene Knockdown Techniques
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Rapamycin inhibits transforming growth factor beta 1 induced myofibroblast differentiation via the phosphorylated-phosphatidylinositol 3-kinase mammalian target of rapamycin signal pathways in nasal polyp-derived fibroblasts.

American journal of rhinology & allergy Nov 1, 2016
PURPOSE: Rapamycin has antiproliferative and antifibrogenic effects in vitro and in vivo. The purpose of this study was to evaluate the effects of rapamycin on transforming growth factor (TGF) beta 1 induced myofibroblast differentiation (alpha smoot...
Humans Cells, Cultured Signal Transduction Fibroblasts Immunosuppressive Agents Myofibroblasts Nasal Polyps Cell Differentiation Transforming Growth Factor beta TOR Serine-Threonine Kinases RNA, Small Interfering Collagen Extracellular Matrix Actins Phosphatidylinositol 3-Kinase Sirolimus
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