Small molecules have been playing a crucial role in drug discovery; however, some exhibit nonspecific inhibitory effects during hit screening due to the formation of colloidal aggregators. Such false positives often lead to significant research costs...
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
May 1, 2025
OBJECTIVE: To outline immune-cell infiltration and identify diagnostic genes for atherosclerosis (AS) to better understand the potential molecular processes involved in AS development.
BACKGROUND: Accurate diagnosis of neuroendocrine neoplasms (NENs) is challenging, especially in poorly differentiated neuroendocrine carcinomas (NECs). This study was aimed to search the best or best combination of neuroendocrine markers in the diagn...
Journal of the American Medical Informatics Association : JAMIA
May 1, 2025
OBJECTIVES: To determine the extent to which current large language models (LLMs) can serve as substitutes for traditional machine learning (ML) as clinical predictors using data from electronic health records (EHRs), we investigated various factors ...
OBJECTIVE AND BACKGROUND: Clinically significant posthepatectomy liver failure (PHLF B+C) remains the main cause of mortality after major hepatic resection. This study aimed to establish an aspartate aminotransferase to platelet ratio combined with a...
BACKGROUND: Breast reduction is a common procedure with growing rates in the United States of America, aimed at alleviating the physical and psychological burdens of macromastia. Despite high success rates, it carries a risk of complications, with in...
BACKGROUND: The accurate and prompt diagnosis of infections is essential for improving patient outcomes and preventing bacterial drug resistance. Host gene expression profiling as an approach to infection diagnosis holds great potential in assisting ...
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Apr 1, 2025
Objective Based on 25 indicators including immune factors, cell count classification, and smear results of the knee joint fluid, machine learning models were established to distinguish between osteoarthritis (OA) and rheumatoid arthritis (RA). Method...
BACKGROUND: Coronary artery plaque rupture (PR) is closely associated with immune-inflammatory responses. The systemic inflammatory index (SII) and the systemic inflammatory response index (SIRI) have shown potential in predicting the occurrence of P...
Journal of evaluation in clinical practice
Apr 1, 2025
BACKGROUND: Neonatal seizures are one of the most prevalent clinical manifestations of neurological conditions, requiring urgent intervention and detection. Machine learning (ML) and Deep Learning (DL) is an emerging promising tool for detecting and ...
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