AIMC Topic: Staphylococcal Infections
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Development and validation of a hierarchical machine learning method using MALDI-TOF mass spectrometry for rapid SCCmec typing and PVL detection in MRSA: a multi-centre study.
Emerging microbes & infections
Dec 1, 2025
OBJECTIVES: Methicillin-resistant (MRSA) is a major public health concern because of its genotypic diversity and association with severe infections, particularly those caused by strains carrying Panton-Valentine leukocidin (PVL). This study aimed to...
Antimicrobial peptide developed with machine learning sequence optimization targets drug resistant Staphylococcus aureus in mice.
The Journal of clinical investigation
Jun 16, 2025
As antimicrobial resistance rises, new antibacterial candidates are urgently needed. Using sequence space information from over 14,743 functional antimicrobial peptides (AMPs), we improved the antimicrobial properties of citropin 1.1, an AMP with wea...
Active capture-directed bimetallic nanosubstrate for enhanced SERS detection of Staphylococcus aureus by combining strand exchange amplification and wavelength-selective machine learning.
Biosensors & bioelectronics
Jun 15, 2025
Staphylococcus aureus (S. aureus) is the leading risk factor for food safety and human health. Herein, a novel wavelength-selective machine learning -driven adaptive strand exchange amplification (SEA)/SERS biosensor was developed for rapid detection...
Prediction of teicoplanin plasma concentration in critically ill patients: a combination of machine learning and population pharmacokinetics.
The Journal of antimicrobial chemotherapy
Nov 4, 2024
BACKGROUND: Teicoplanin has been widely used in patients with infections caused by Staphylococcus aureus, especially for critically ill patients. The pharmacokinetics (PK) of teicoplanin vary between individuals and within the same individual. We aim...
A Machine Learning-Based Risk Score for Prediction of Infective Endocarditis Among Patients With Staphylococcus aureus Bacteremia-The SABIER Score.
The Journal of infectious diseases
Sep 23, 2024
BACKGROUND: Early risk assessment is needed to stratify Staphylococcus aureus infective endocarditis (SA-IE) risk among patients with S. aureus bacteremia (SAB) to guide clinical management. The objective of the current study was to develop a novel r...
Large-scale mass spectrometry data combined with demographics analysis rapidly predicts methicillin resistance in Staphylococcus aureus.
Briefings in bioinformatics
Jul 20, 2021
BACKGROUND: A mass spectrometry-based assessment of methicillin resistance in Staphylococcus aureus would have huge potential in addressing fast and effective prediction of antibiotic resistance. Since delays in the traditional antibiotic susceptibil...
A large-scale investigation and identification of methicillin-resistant Staphylococcus aureus based on peaks binning of matrix-assisted laser desorption ionization-time of flight MS spectra.
Briefings in bioinformatics
May 20, 2021
Recent studies have demonstrated that the matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) could be used to detect superbugs, such as methicillin-resistant Staphylococcus aureus (MRSA). Due to an increasingl...
Antimicrobial and synergistic activity of thiazoline derivatives in combination with conventional antibiotics against multidrug resistant Staphylococcus aureus isolated from abscess drainage samples.
Pakistan journal of pharmaceutical sciences
Sep 1, 2020
Emergence and spread of multidrug resistant (MDR) Staphylococcus aureus strains is becoming major challenge in treatment of soft tissue infections. This study aimed to explore antimicrobial and synergistic antimicrobial potential of three commerciall...
A simplified chart for determining the initial loading dose of teicoplanin in critically ill patients.
Die Pharmazie
Jan 10, 2017
AIM OF THE STUDY: A simplified chart to determine the initial loading dose of teicoplanin (TEIC chart) for achieving the target trough concentration was developed. The aim of the present study was to evaluate the usefulness of this chart in criticall...
[EFFECT OF INFECTION ON CAPSULE FORMATION AFTER BREAST IMPLANTS].
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Dec 1, 2015
OBJECTIVE: To investigate the correlation between infection and capsular contracture by observing the effect of infection on the formation of the surrounding capsule after breast implants.
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