The pathogenesis of diabetic cardiomyopathy (DCM) remains incompletely understood. The present study employed weighted gene co‑expression network analysis to analyze the DCM transcriptome dataset from the Gene Expression Omnibus (GEO) database to ide...
Transcriptomic data analysis entails the measurement of RNA transcript (gene expression products) abundance in a cell or a cell population at a single point in time. In other words, transcriptomics as it is currently practiced is two-dimensional (2DT...
Endometrial adenocarcinoma carries a bleak prognosis, and the molecular markers that evaluate the progression of endometrial adenocarcinoma to advanced stages remain uncertain. Cell-cell communication plays a crucial role in the tumor microenvironmen...
UNLABELLED: Early cancer diagnosis is crucial but challenging owing to the lack of reliable biomarkers that can be measured using routine clinical methods. The identification of biomarkers for early detection is complicated by each tumor involving ch...
Journal of cellular and molecular medicine
Jul 1, 2025
BACKGROUND: The global increase in thyroid cancer prevalence, particularly among female populations, underscores critical gaps in our understanding of molecular pathogenesis and diagnostic capabilities. Our investigation addresses these knowledge def...
Toxicological sciences : an official journal of the Society of Toxicology
Jul 1, 2025
Transcriptomic analyses have been an effective approach to investigate the biological responses and metabolic perturbations by environmental contaminants in rodent models. However, it is well recognized that metabolic networks are highly connected an...
Clinical and experimental pharmacology & physiology
Jul 1, 2025
Sepsis is a life-threatening disease caused by the dysregulation of the immune response. It is important to identify influential genes modulating the immune response in sepsis. In this study, we used P-NET, a biologically informed explainable artific...
BACKGROUND: The immune microenvironment significantly influences neural regeneration in spinal cord injury (SCI). Lactate activates central nervous system (CNS) glial cells, prompting the secretion of proinflammatory cytokines and triggering an infla...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jun 30, 2025
Heterotopic ossification (HO) is a pathological process where bone forms in extraskeletal tissues, often occurring as a complication of tissue repair following injury. This condition can lead to movement limitations, pain, and functional impairment. ...
Progress in neuro-psychopharmacology & biological psychiatry
Jun 20, 2025
BACKGROUND: For suicide in major depression disorder, it is urgent to seek for a reliable neuroimaging biomarker with interpretable links to molecular tissue signatures. Accordingly, we developed an ensemble learning scheme over transcriptome-defined...
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