AIMC Journal:
International journal of molecular sciences
Showing 401 to 410 of 423 articles
PCLPred: A Bioinformatics Method for Predicting Protein-Protein Interactions by Combining Relevance Vector Machine Model with Low-Rank Matrix Approximation.
International journal of molecular sciences
Mar 29, 2018
Protein-protein interactions (PPI) are key to protein functions and regulations within the cell cycle, DNA replication, and cellular signaling. Therefore, detecting whether a pair of proteins interact is of great importance for the study of molecular...
PON-tstab: Protein Variant Stability Predictor. Importance of Training Data Quality.
International journal of molecular sciences
Mar 28, 2018
Several methods have been developed to predict effects of amino acid substitutions on protein stability. Benchmark datasets are essential for method training and testing and have numerous requirements including that the data is representative for the...
Urinary Polyamine Biomarker Panels with Machine-Learning Differentiated Colorectal Cancers, Benign Disease, and Healthy Controls.
International journal of molecular sciences
Mar 7, 2018
Colorectal cancer (CRC) is one of the most daunting diseases due to its increasing worldwide prevalence, which requires imperative development of minimally or non-invasive screening tests. Urinary polyamines have been reported as potential markers to...
Key Clinical Factors Predicting Adipokine and Oxidative Stress Marker Concentrations among Normal, Overweight and Obese Pregnant Women Using Artificial Neural Networks.
International journal of molecular sciences
Dec 28, 2017
Maternal obesity has been related to adverse neonatal outcomes and fetal programming. Oxidative stress and adipokines are potential biomarkers in such pregnancies; thus, the measurement of these molecules has been considered critical. Therefore, we d...
Case-Control Studies
Oxidative Stress
Malondialdehyde
Body Mass Index
Female
Adult
Severity of Illness Index
Gene Expression
8-Hydroxy-2'-Deoxyguanosine
Protein Carbonylation
Leptin
Age Factors
Obesity
DNA
Biomarkers
Pregnancy
Humans
Neural Networks, Computer
Pregnancy Trimester, Third
Adiponectin
Deoxyguanosine
Gestational Age
Resistin
Indoleamine 2,3-Dioxygenase (IDO) Enzyme Links Innate Immunity and Altered T-Cell Differentiation in Non-ST Segment Elevation Acute Coronary Syndrome.
International journal of molecular sciences
Dec 26, 2017
Atherosclerosis is a chronic inflammatory disease characterized by a complex interplay between innate and adaptive immunity. Dendritic cells (DCs) play a key role in T-cell activation and regulation by promoting a tolerogenic environment through the ...
Leptin Stimulates Prolactin mRNA Expression in the Goldfish Pituitary through a Combination of the PI3K/Akt/mTOR, MKK/pMAPK and MEK/ERK Signalling Pathways.
International journal of molecular sciences
Dec 20, 2017
Leptin actions at the pituitary level have been extensively investigated in mammalian species, but remain insufficiently characterized in lower vertebrates, especially in teleost fish. Prolactin (PRL) is a pituitary hormone of central importance to o...
Activation of PPARα by Oral Clofibrate Increases Renal Fatty Acid Oxidation in Developing Pigs.
International journal of molecular sciences
Dec 8, 2017
The objective of this study was to evaluate the effects of peroxisome proliferator-activated receptor α (PPARα) activation by clofibrate on both mitochondrial and peroxisomal fatty acid oxidation in the developing kidney. Ten newborn pigs from 5 litt...
Azithromycin and Chloramphenicol Diminish Neutrophil Extracellular Traps (NETs) Release.
International journal of molecular sciences
Dec 8, 2017
Neutrophils are one of the first cells to arrive at the site of infection, where they apply several strategies to kill pathogens: degranulation, respiratory burst, phagocytosis, and release of neutrophil extracellular traps (NETs). Antibiotics have a...
Comparative Analysis of the Cytology and Transcriptomes of the Cytoplasmic Male Sterility Line H276A and Its Maintainer Line H276B of Cotton (Gossypium barbadense L.).
International journal of molecular sciences
Oct 25, 2017
In this study, the tetrad stage of microspore development in a new cotton ( L.) cytoplasmic male sterility (CMS) line, H276A, was identified using paraffin sections at the abortion stage. To explore the molecular mechanism underlying CMS in cotton, a...
CytoCluster: A Cytoscape Plugin for Cluster Analysis and Visualization of Biological Networks.
International journal of molecular sciences
Aug 31, 2017
Nowadays, cluster analysis of biological networks has become one of the most important approaches to identifying functional modules as well as predicting protein complexes and network biomarkers. Furthermore, the visualization of clustering results i...
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