In a time of rapid advances in science and technology, the opportunities for radiation oncology are undergoing transformational change. The linkage between and understanding of the physical dose and induced biological perturbations are opening entire...
BACKGROUND: Benign breast disease (BBD) is a strong breast cancer risk factor, but identifying patients that might develop invasive breast cancer remains a challenge.
BACKGROUND: New biomarkers of risk may improve breast cancer (BC) risk prediction. We developed a computational pathology method to segment benign breast disease (BBD) whole slide images into epithelium, fibrous stroma, and fat. We applied our method...
BACKGROUND: Observational data support inverse relationships between exercise or metformin use and disease outcomes in colorectal and breast cancer survivors, although the mechanisms underlying these associations are not well understood.
BACKGROUND: Circulating cell-free DNA (cfDNA) is a proposed latent biomarker for several cancers, including liver cancer. Deoxyribonucleases (DNases) facilitate the timely and efficient degradation of cfDNA, leading us to hypothesize that DNase I and...
Clinical trials are fundamental to evidence-based medicine, providing patients with access to novel therapeutics and advancing scientific knowledge. However, patient comprehension of trial information remains a critical challenge, as registries like ...
BACKGROUND: Adequate patient awareness and understanding of cancer clinical trials is essential for trial recruitment, informed decision making, and protocol adherence. Although large language models (LLMs) have shown promise for patient education, t...
BACKGROUND: Cancer patients have up to a 3-fold higher risk for cardiovascular disease (CVD) than the general population. Traditional CVD risk scores may be less accurate for them. We aimed to develop cancer-specific CVD risk scores and compare them ...