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Effect of visceral fat on onset of metabolic syndrome.
Scientific reports
May 30, 2025
This study analysed the effects of visceral fat on metabolic syndrome (MetS) and developed an algorithm to predict its onset using health examination data from the Iwaki Health Promotion Project in Japan. The dataset included 213 cases of MetS onset ...
Integrated plasma and vegetation proteomic characterization of infective endocarditis for early diagnosis and treatment.
Nature communications
May 30, 2025
Infective endocarditis, a life-threatening condition, poses challenges for early diagnosis and personalized treatment due to insufficient biomarkers and limited understanding of its pathophysiology. Here, we performed proteomic profiling of plasma an...
Development and validation of the Immune Profile Score (IPS), a novel multiomic algorithmic assay for stratifying outcomes in a real-world cohort of patients with advanced solid cancer treated with immune checkpoint inhibitors.
Journal for immunotherapy of cancer
May 30, 2025
BACKGROUND: Immune checkpoint inhibitors (ICIs) have transformed the oncology treatment landscape. Despite substantial improvements for some patients, the majority do not benefit from ICIs, indicating a need for predictive biomarkers to better inform...
Physical and mental health management for the older adult using XGBoost algorithm supported by new media technology: developing personalized health intervention plans using healthcare data from the CLHLS database.
Frontiers in public health
May 30, 2025
INTRODUCTION: With the increasing aging population, there is a growing need for precise and intelligent health management solutions tailored to older adult individuals. This study proposes a comprehensive digital health management platform that integ...
Divergent Immune Pathways in Coronary Artery Disease and Aortic Stenosis: The Role of Chronic Inflammation and Senescence.
International journal of molecular sciences
May 29, 2025
Coronary artery disease (CAD) remains a major cause of cardiovascular morbidity and mortality, with growing evidence linking immune dysregulation to its pathogenesis. Aortic stenosis often coexists with CAD (ASCAD), representing an advanced disease f...
A preliminary study of the reliability and validity of the Uyghur version of the NUCOG cognitive screening application.
BMC neurology
May 29, 2025
INTRODUCTION: Technological advances and artificial intelligence now make it feasible to administer cognitive assessments on touch-screen devices. The aim of this study is to develop a Uyghur version of the NUCOG cognitive screening application and e...
Associations of greenhouse gases, air pollutants and dynamics of scrub typhus incidence in China: a nationwide time-series study.
BMC public health
May 29, 2025
BACKGROUND: Environmental factors have been identified as significant risk factors for scrub typhus. However, the impact of inorganic compounds such as greenhouse gases and air pollutants on the incidence of scrub typhus has not been evaluated.
Decoding dynamic brain networks in Parkinson's disease with temporal attention.
Scientific reports
May 29, 2025
Detecting brief, clinically meaningful changes in brain activity is crucial for understanding neurological disorders. Conventional imaging analyses often overlook these subtle events due to computational demands. IMPACT (Integrative Multimodal Pipeli...
Menopausal hormone therapy and the female brain: Leveraging neuroimaging and prescription registry data from the UK Biobank cohort.
eLife
May 29, 2025
BACKGROUND: Menopausal hormone therapy (MHT) is generally thought to be neuroprotective, yet results have been inconsistent. Here, we present a comprehensive study of MHT use and brain characteristics in females from the UK Biobank.
An integrated analytical approach for biomarker discovery in esophageal cancer: Combining trace element and oxidative stress profiling with machine learning.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
May 28, 2025
BACKGROUND: Early detection of esophageal squamous cell carcinoma (ESCC) significantly improves survival rates, yet reliable biochemical biomarkers for early diagnosis remain limited. The aim of this study is to identify potential early diagnostic bi...
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