AIMC Topic: Aged

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Prediction of cervical cancer lymph node metastasis based on multisequence magnetic resonance imaging radiomics and deep learning features: a dual-center study.

Scientific reports
Cervical cancer is a leading cause of death from malignant tumors in women, and accurate evaluation of occult lymph node metastasis (OLNM) is crucial for optimal treatment. This study aimed to develop several predictive models-including Clinical mode...

Development and validation of a machine learning model for predicting vulnerable carotid plaques using routine blood biomarkers and derived indicators: insights into sex-related risk patterns.

Cardiovascular diabetology
BACKGROUND: Early detection of vulnerable carotid plaques is critical for stroke prevention. This study aimed to develop a machine learning model based on routine blood tests and derived indices to predict plaque vulnerability and assess sex-specific...

Deep Learning-aided H-MR Spectroscopy for Differentiating between Patients with and without Hepatocellular Carcinoma.

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
PURPOSE: Among patients with hepatitis B virus-associated liver cirrhosis (HBV-LC), there may be differences in the hepatic parenchyma between those with and without hepatocellular carcinoma (HCC). Proton MR spectroscopy (H-MRS) is a well-established...

Serum peptide biomarkers by MALDI-TOF MS coupled with machine learning for diagnosis and classification of hepato-pancreato-biliary cancers.

Scientific reports
This study aimed to investigate the potential of peptide mass fingerprints (PMFs) of the serum peptidome using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), in combination with machine learning algorithm...

Exploring the feasibility of AI-based analysis of histopathological variability in salivary gland tumours.

Scientific reports
This study uses artificial intelligence (AI) for differentiation between salivary gland tumours (SGT) using digitised Haematoxylin and Eosin stained whole-slide images (WSI). Machine learning (ML) classifiers were developed and tested using 320 scann...

Development and validation of interpretable machine learning models for predicting AKI risk in patients treated with PD-1/PD-L1: a retrospective study.

BMC medical informatics and decision making
BACKGROUND: Anti-programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) immunotherapy has revolutionized cancer treatment. However, it can cause immune-related adverse events, including acute kidney injury (AKI). Such adverse e...

Machine learning based analysis of leucocyte cell population data by Sysmex XN series hematology analyzer for the diagnosis of bacteremia.

Scientific reports
In clinical practice, early recognition of bacteremia leads to prognostic improvement. Recently, cell population data (CPD) from the Sysmex XN-series hematology analyzer has attracted attention as a new method for the early diagnosis of bacteremia, b...

Breast cancer is detectable from peripheral blood using machine learning over T cell receptor repertoires.

NPJ systems biology and applications
The immune system's defense abilities rely on the diversity of T and B lymphocytes. T Cell Receptors (TCRs) are generated through V(D)J recombination, where distinct genetic elements combine and undergo modifications, creating extensive variability. ...

MRI-based radiomics for preoperative T-staging of rectal cancer: a retrospective analysis.

International journal of colorectal disease
PUROPOSE: Preoperative T-staging in rectal cancer is essential for treatment planning, yet conventional MRI shows limited accuracy (~ 60-78). Our study investigates whether radiomic analysis of high-resolution T2-weighted MRI can non-invasively impro...

Human multiethnic radiogenomics reveals low-abundancy microRNA signature in plasma-derived extracellular vesicles for early diagnosis and molecular subtyping of pancreatic cancer.

eLife
Pancreatic cancer (PC) is a highly aggressive malignancy in humans, where early diagnosis significantly improves patient outcomes. However, effective methods for accurate and early detection remain limited. In this multiethnic study involving human s...