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alpha-Amylases

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In Vitro Investigation of Potential Anti-Diabetic Activity of the Corm Extract of Hypoxis Argentea Harv. Ex Baker.

Acta pharmaceutica (Zagreb, Croatia)
The corms of Hypoxis argentea are widely used as a traditional remedy for diabetes mellitus in South Africa. In this study, we investigated the effects of non-toxic concentrations (12.5-100 μg mL-1) of the aqueous extract of H. argentea (HAA) corms o...

Acalypha Wilkesiana 'Java White': Identification of Some Bioactive Compounds by Gc-Ms and Their Effects on Key Enzymes Linked to Type 2 Diabete.

Acta pharmaceutica (Zagreb, Croatia)
In this study, we identified bioactive compounds from the ethanolic extracts of the leaves, stem bark and root bark of Acalypha wilkesiana through GC-MS analysis and investigated the effects of these extracts on some of the enzymes linked to type 2 d...

Anabasis aretioides Coss. & Moq. phenolic compounds exhibit in vitro hypoglycemic, antioxidant and antipathogenic properties.

Journal of basic and clinical physiology and pharmacology
Background Based on our previous ethnobotanical survey, the non-investigated Saharan plant Anabasis aretioides Coss. & Moq., growing in the region of Errachidia, was selected for pharmacological investigation. In Moroccan traditional medicine, A. are...

The involvement of phenolic-rich extracts from Galician autochthonous extra-virgin olive oils against the α-glucosidase and α-amylase inhibition.

Food research international (Ottawa, Ont.)
'Brava' and 'Mansa de Figueiredo' extra-virgin olive oils (EVOOs) are two varieties identified from north-western Spain. A systematic phenolic characterization of the studied oils was undertaken by LC-ESI-IT-MS. In addition, the role of dietary polyp...

Inhibitory activity of phenolic-rich pistachio green hull extract-enriched pasta on key type 2 diabetes relevant enzymes and glycemic index.

Food research international (Ottawa, Ont.)
Phenolic compounds as agro-industrial by-products have been associated with health benefits since they exhibit high antioxidant activity and anti-diabetic properties. In this study, polyphenol-rich extract from pistachio green hull (PGH) was evaluate...

Changes in polyphenol composition and bioactivity of the native Chilean white strawberry (Fragaria chiloensis spp. chiloensis f. chiloensis) after in vitro gastrointestinal digestion.

Food research international (Ottawa, Ont.)
The Chilean white strawberry (Fragaria chiloensis spp. chiloensis f. chiloensis) is a semi-domesticated strawberry with high polyphenol content and antioxidant activity occurring in southern Chile. The aim of this work was to compare the composition ...

Variations of the chemical components and biological activities of Thymus capitatus essential oil from three regions in Palestine.

Scientific reports
Thymus capitatus is a widely utilized medicinal plant in Palestine. The main goal of this study was to assess the phytochemical content of T. capitatus essential oils (EOs) from three Palestinian regions using hydro-distillation. Furthermore, the EO ...

Antibiofilm Activity of α-Amylase from Bacillus subtilis and Prediction of the Optimized Conditions for Biofilm Removal by Response Surface Methodology (RSM) and Artificial Neural Network (ANN).

Applied biochemistry and biotechnology
α-amylase is known to have antibiofilm activity against biofilms of both Gram positive and Gram-negative bacterial strains. Partially purified α-amylase from Bacillus subtilis was found to have inhibit biofilm formed by P. aeruginosa and S. aureus. T...

Exploring the potential of machine learning to design antidiabetic molecules: a comprehensive study with experimental validation.

Journal of biomolecular structure & dynamics
Recent advances in hardware and software algorithms have led to the rise of data-driven approaches for designing therapeutic modalities. One of the major causes of human mortality is diabetes. Thus, there is a tremendous opportunity for research into...

Deep eutectic solvent-based green extraction of Strychnos potatorum seed phenolics: Process optimization via response surface methodology and artificial neural network.

Talanta
The current research focused on extraction optimization of bioactive compounds from Strychnos potatorum seeds (SPs) using an eco-friendly glycerol-sodium acetate based deep eutectic solvent (DES). The optimization was accomplished using response surf...