AIMC Topic: Animals

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The Central Role of m6A as Epigenetic Regulator in Metabolic Disorders of Therapeutic Potential and Clinical Implications.

Molecular neurobiology
N6-methyladenosine (m6A) is the most common reversible mRNA modification, regulating fundamental cellular processes. It plays a vital role in aging and age-related diseases by influencing gene expression, RNA splicing, and stability. Growing evidence...

Advances in surrogate modeling for biological agent-based simulations: trends, challenges, and future prospects.

Journal of mathematical biology
Agent-based modeling (ABM) is a powerful computational approach for studying complex biological and biomedical systems, yet its widespread use remains limited by significant computational demands. As models become increasingly sophisticated, the numb...

Acoustic analysis of bottlenose dolphin vocalizations for behavioral classification in controlled settings.

PloS one
Understanding how bottlenose dolphins adjust their vocal behavior in response to daily routines can provide insights into social communication and welfare assessment in managed care environments. This study presents a detailed analysis of bottlenose ...

A bioavailable 87Sr/86Sr isoscape of Mongolia: Implications for the reconstruction of past human and animal mobility.

PloS one
Understanding past human and animal mobility is essential for reconstructing the social and cultural dynamics of ancient societies. Strontium isotope analysis (87Sr/86Sr) offers a powerful tool to investigate provenance and movement. The bioavailable...

Anthocyanins loaded bilayer films based on polysaccharides assisted by machine learning for fish freshness monitoring.

Food chemistry
Novel multifunctional packaging for monitoring and maintaining food freshness has been developed. Bilayer films based on polysaccharides incorporating red cabbage anthocyanins were prepared. Anthocyanins were encapsulated in the inner layer based on ...

A new approach improving koala habitat prediction using hyperspectral airborne imagery.

The Science of the total environment
Koala populations are declining primarily due to habitat loss, making large-scale habitat quality prediction essential for conservation. A first approach to defining koala habitat quality involves identifying the number of different 'koala' trees spe...

AI-driven discovery of antiretroviral drug bictegravir and etravirine as inhibitors against monkeypox and related poxviruses.

Communications biology
Monkeypox virus (MPXV) caused the 2022-2023 global mpox and the concurrent outbreaks in Africa, disproportionately affecting immunocompromised individuals such as people living with HIV. With no approved treatment available, we developed a robust art...

Machine learning-based prediction of drug response in ischemia reperfusion animal model.

Scientific reports
Myocardial ischemia is a major global contributor to mortality. While reperfusion therapy remains the most effective treatment, it paradoxically leads to myocardial ischemia-reperfusion (MI/R) injury, resulting in irreversible cardiac damage for whic...

Microbial Product Cocktails for Personalized Cancer Immunotherapy.

Nature communications
The human immune system has evolved to interact with various commensal and pathogenic bacteria in intricate and nuanced ways. While the diversity of bacteria presents fundamental challenges in understanding immune-microbe interactions, it also offers...

Spatial omics: applications and utility in profiling the tumor microenvironment.

Cancer metastasis reviews
Spatial transcriptomics has emerged as a transformative technology in biomedical research, offering unprecedented insights into gene and protein expression within their native tissue context. Unlike conventional bulk or single-cell sequencing approac...