Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 12, 2024
Endometriosis affects over 190 million women globally, and effective therapies are urgently needed to address the burden of endometriosis on women's health. Using an artificial intelligence (AI)-driven target discovery platform, two unreported therap...
Human dose prediction (HDP) is a useful tool for compound optimization in preclinical drug discovery. We describe here our exclusively in silico HDP strategy to triage compound designs for synthesis and experimental profiling. Our goal is a model tha...
Proceedings of the National Academy of Sciences of the United States of America
Dec 12, 2024
Delivering medical agents to diseased tissues has been challenging, leading researchers to study the in vivo transport process in the body for improving delivery. Many imaging techniques exist for mapping the distribution of medical agent-carrying na...
OBJECTIVE: Subarachnoid hemorrhage (SAH) and tumorigenesis share numerous biological complexities; nevertheless, the specific gene expression profiles and underlying mechanisms remain poorly understood. This study aims to identify differentially expr...
Coccidiosis is a gastrointestinal parasitic disease caused by different species of Eimeria and Isospora, poses a significant threat to pig farming, leading to substantial economic losses attributed to reduced growth rates, poor feed conversion, incre...
(Nb) has been considered a dangerous pathogen, which can spread rapidly through free spores. Nowadays, pebrine disease caused by Nb spores is a serious threat to silkworms, causing huge economic losses in both the silk industry and agriculture every...
Journal of chemical information and modeling
Dec 11, 2024
Cytotoxicity is essential in drug discovery, enabling early evaluation of toxic compounds during screenings to minimize toxicological risks. assays support high-throughput screening, allowing for efficient detection of toxic substances while conside...
Biomolecular condensates are membraneless organelles that can concentrate hundreds of different proteins in cells to operate essential biological functions. However, accurate identification of their components remains challenging and biased towards p...
Micro- and nanorobots excel in navigating the intricate and often inaccessible areas of the human body, offering immense potential for applications such as disease diagnosis, precision drug delivery, detoxification, and minimally invasive surgery. De...
BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) and the thyrotropin receptor (TSH-R) are expressed on orbital cells and thyrocytes. These receptors are targeted in autoimmune-induced thyroid eye disease (TED). Effective therapeutic tre...
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