Alzheimer's disease (AD), acknowledged as the leading cause of dementia, is defined by the accumulation of amyloid plaques and neurofibrillary tangles (NFTs) in the brain. This condition presents a significant challenge to global health due to its co...
Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant liver cancer with limited treatment options. Recent evidence implicates lactate metabolism as playing a crucial role in tumor progression, but its precise contribution in iCCA remains uncle...
Langmuir : the ACS journal of surfaces and colloids
Dec 25, 2025
Protein adsorption on surfaces is a highly complex process, governed by intricate interactions between protein, surface and surrounding environment. However, accurately predicting protein adsorption amounts and precisely controlling adsorption behavi...
Mass spectrometry (MS)-based proteomics is a disruptive platform in drug discovery that offers an exhaustive view of the proteome's complexity. Focusing on bottom-up MS proteomics, this technology enables high-throughput analysis of protein expressio...
Micro-computed tomography (μCT) provides 3D images of congenital heart defects (CHD) in mice. However, diagnosing CHD from μCT scans is time-consuming and requires clinical expertise. Here, we present a deep learning approach to automatically segment...
Trained Immunity is the nonspecific (pathogen agnostic) memory of innate immune cells, characterized by altered responses upon secondary stimulation. This review provides a RoadMap for the discovery and development of therapeutics targeting Trained I...
Hypertension is a leading cause of mortality worldwide, for which myriad treatment options are available. It is widely considered that continuous measurement of arterial blood pressure (BP) could improve the treatment of hypertension; however, chroni...
Biological phenotyping of cellular metabolism is essential for deciphering health and disease states. The Seahorse XF analyzer enables direct measurement of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR), providing insight ...
BACKGROUND: Neurovascular biomarkers have the potential to enhance early diagnosis of Alzheimer's disease (AD) and AD-related dementias (ADRD), as cerebrovascular alterations often precede neurodegeneration. However, their clinical application remain...
Chordoma is an unique and aggressive bone malignancy along with limited therapeutic options, largely due to the undruggable nature of the TBXT oncoprotein. In this study, we employed an AI-assisted drug discovery approach to optimize β-sitosterol fro...
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