AIMC Topic: Animals

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Rapid, interpretable data-driven models of neural dynamics using recurrent mechanistic models.

Proceedings of the National Academy of Sciences of the United States of America
Obtaining predictive models of a neural system is notoriously challenging. Detailed models suffer from excess model complexity and are difficult to fit efficiently. Simplified models must negotiate a tradeoff between tractability, predictive power, a...

Prevalence, associated risk factors and satellite imagery analysis in predicting soil-transmitted helminth infection in Nakhon Si Thammarat Province, Thailand.

Scientific reports
Soil-transmitted helminth (STH) infections remain a significant public health concern in rural areas, often leading to nutritional and physical impairment, particularly in children. This study aimed to assess the prevalence and associated factors of ...

Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis.

Nature communications
Current first-line treatments of paediatric ulcerative colitis (UC) maintain a 6-month remission in only half of the patients. Relapse prediction at diagnosis could enable earlier introduction of immunosuppressants. We collected intestinal biopsies f...

A multisynaptic spiking neuron for simultaneously encoding spatiotemporal dynamics.

Nature communications
Spiking neural networks (SNNs) are biologically more plausible and computationally more powerful than artificial neural networks due to their intrinsic temporal dynamics. However, vanilla spiking neurons struggle to simultaneously encode spatiotempor...

NAFLD progression in metabolic syndrome: a Raman spectroscopy and machine learning approach in an animal model.

The Analyst
Nonalcoholic fatty liver disease (NAFLD) is emerging as the leading cause of chronic liver disease in many regions, particularly in association with the rising prevalence of Metabolic syndrome (MetS), affecting more than 30% of the population worldwi...

Multi-omics analysis of plasma and CSF in spontaneous diabetic cynomolgus monkeys: Unravelling and validating the key molecular markers that predict the preclinical pathological formation of Alzheimer's disease.

Computers in biology and medicine
Alzheimer's disease (AD) biomarkers (Aβ42 or Tau 181) have high diagnostic performance. However, when they are altered, it indicates that irreversible pathology has developed in the brain. Therefore, there is a lack of early prediction or monitoring ...

Detection of Unlabeled Polystyrene Micro- and Nanoplastics in Mammalian Tissue by Optical Photothermal Infrared Spectroscopy.

Analytical chemistry
In this study, we investigate the efficacy of optical photothermal infrared (O-PTIR) spectroscopy, also known as mid-infrared photothermal (MIP) microscopy, for label-free and nondestructive detection of micro- and nanoplastics (MNPs) down to diamete...

Prediction of blown pack in vacuum-packaged beef based on microbiome profiles and supervised machine learning.

International journal of food microbiology
The preservation of vacuum-packaged beef products is essential for maintaining shelf life. However, the occurrence of blown pack phenomenon, characterized by the expansion of packaging due to gas production by spoilage microorganisms, is still a chal...

Risk assessment of corn borer based on feature optimization and weighted spatial clustering: a case study in Shandong Province, China.

Scientific reports
As a typical pest affecting corn yield and safety, corn borer causes serious economic losses worldwide. Climate warming has intensified the occurrence of pest outbreaks in recent years, but the associated risk has not been precisely assessed or under...

Integrative network pharmacology and multi-omics reveal anisodamine hydrobromide's multi-target mechanisms in sepsis.

Scientific reports
Sepsis, marked by hyperinflammation and subsequent immunosuppression, lacks effective phase-specific therapies. Although anisodamine hydrobromide (Ani HBr) reduced 28-day mortality in our prior trial, its mechanisms remained unclear. Here, we integra...