AIMC Topic: Animals

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Leveraging unsupervised machine learning techniques for detecting outliers in the daily milk yield data of dairy cows.

Journal of dairy science
The lactation curve is essential for developing effective feeding plans, optimizing breeding, and strategizing milk production for dairy farms. However, health disorders, as well as external factors such as heat stress, dietary changes, and certain m...

Roadmap for Commercial Nanomedicine Development: Integrating Quality by Design Principles with Pharmaceutical Nanotechnology.

Molecular pharmaceutics
Integrating Quality by Design (QbD) principles into nanomedicine development marks a paradigm shift from traditional empirical approaches to more systematic risk-based strategies. This review explores the application of QbD in pharmaceutical nanotech...

Association of artificial intelligence-predicted milk yield residuals to behavioral patterns and transition success in multiparous dairy cows.

Journal of dairy science
Data-driven health monitoring based on milk yield has shown potential to identify health-perturbing events during the transition period. As a proof of principle, we explored the association between the cow's residual milk yield, that is, the differen...

Machine Learning-Based Screening of Cosmetic Ingredients Identifies Vat Blue 6 as a Thyroid Hormone Receptor β Disruptor.

Environmental science & technology
Thyroid disorders are among the most prevalent endocrine conditions worldwide, exhibiting a rising incidence and disproportionately affecting women. In this study, we hypothesized that cosmetics may contain previously unidentified thyroid-disrupting ...

Tetanus-driven biohybrid multijoint robots powered by muscle rings with enhanced contractile force.

Science advances
Biohybrid actuators using muscle rings have been limited to twitching movements and are unsuitable for sustained contractile force applications. In this study, we developed muscle rings capable of generating high contractile forces under tetanus stim...

A forward-engineered, muscle-driven soft robotic swimmer.

Science advances
The field of biohybrid robotics focuses on using biological actuators to study the emergent properties of tissues and the locomotion of living organisms. On the basis of models of swimming at small size scales, we designed and fabricated a muscle-pow...

Innovative organ-on-a-chip platforms for exploring tumorigenesis and therapy in head and neck cancer.

Journal of translational medicine
BACKGROUND: Head and neck cancer (HNC) presents significant research challenges due to the complexity of its tumor microenvironment (TME) and the heterogeneity across different cancer subtypes. Recent advancements in three-dimensional (3D) culture mo...

Exploration of Predictive Potential of AI-enabled Portable System in Anticancer Drug Delivery: A Comparative Study with Modified Gompertz like Biphasic Response Model.

AAPS PharmSciTech
Mathematical models are conventionally used to understand the of tumor behaviors, but they generally lack in precisely correlating drug efficacy with tumor response. Artificial intelligence (AI) has forged a new avenue in cancer management, but requi...

Deep learning-based high-resolution time inference for deciphering dynamic gene regulation from fixed embryos.

Nature communications
Embryo development is driven by the spatiotemporal dynamics of complex gene regulatory networks. Uncovering these dynamics requires simultaneous tracking of multiple fluctuating molecular species over time, which exceeds the capabilities of tradition...

Surgical embodied intelligence for generalized task autonomy in laparoscopic robot-assisted surgery.

Science robotics
Surgical robots capable of autonomously performing various tasks could enhance efficiency and augment human productivity in addressing clinical needs. Although current solutions have automated specific actions within defined contexts, they are challe...