AIMC Topic: Animals

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Applying computational protein design to therapeutic antibody discovery - current state and perspectives.

Frontiers in immunology
Machine learning applications in protein sciences have ushered in a new era for designing molecules in silico. Antibodies, which currently form the largest group of biologics in clinical use, stand to benefit greatly from this shift. Despite the prol...

Fidelity to territory and mate and the causes and consequences of breeding dispersal in American goshawk (Astur atricapillus).

PloS one
Using mark-resight data, we investigated fidelity to territory and mate as well as breeding dispersal rates and the causes and consequences of breeding dispersal in a 20-year study of American goshawks (Astur atricapillus) in Arizona, USA. Generalize...

Evaluating methods for the prediction of cell-type-specific enhancers in the mammalian cortex.

Cell genomics
Identifying cell-type-specific enhancers is critical for developing genetic tools to study the mammalian brain. We organized the "Brain Initiative Cell Census Network (BICCN) Challenge: Predicting Functional Cell Type-Specific Enhancers from Cross-Sp...

Preliminary Development of a Database for Detecting Active Mounting Behaviors Using Signals Acquired from IoT Collars in Free-Grazing Cattle.

Sensors (Basel, Switzerland)
This study presents the development of a database for detecting active mounts, utilizing IoT collars equipped with Inertial Measurement Units (IMUs) installed on eight Holstein Friesian cows, along with video recordings from a long-range PTZ camera m...

Establishment of a prognostic model based on ER stress-related cell death genes and proposing a novel combination therapy in acute myeloid leukemia.

Journal of translational medicine
BACKGROUND: Acute myeloid leukemia (AML) is a highly heterogeneous malignancy, presenting significant challenges in accurately predicting patient prognosis. Dysregulation of endoplasmic reticulum (ER) stress and resistance to programmed cell death (P...

CMImpute: cross-species and tissue imputation of species-level DNA methylation samples across mammalian species.

Genome biology
The large-scale application of the mammalian methylation array has substantially expanded the availability of DNA methylation data in mammalian species. However, this data captures only a small portion of species-tissue combinations. To address this,...

Antifungal activity and mechanism of novel peptide antimicrobial peptide (GmAMP) against fluconazole-resistant .

PeerJ
BACKGROUND: There is a pressing need to create innovative alternative treatment approaches considering the overuse of antifungal drugs causes the number of clinically isolated fluconazole-resistant species to increase. antimicrobial peptide (GmAMP)...

SwinFishNet: A Swin Transformer-based approach for automatic fish species classification using transfer learning.

PloS one
The fish market is a crucial industry for both domestic economies and the global seafood trade. Accurate fish species classification (FSC) plays a significant role in ensuring sustainability, improving food safety, and optimizing market efficiency. T...

Intestinal permeability of N-acetylcysteine is driven by gut microbiota-dependent cysteine palmitoylation.

Nature communications
Trillions of intestinal microbiota are essential to the permeability of orally administered drugs. However, identifying microbial-drug interactions remains challenging due to the highly variable composition of intestinal flora among individuals. Usin...

Hierarchical design of silkworm silk for functional composites.

Chemical Society reviews
Silk-reinforced composites (SRCs) manifest the unique properties of silkworm silk fibers, offering enhanced mechanical strength, biocompatibility, and biodegradability. These composites present an eco-friendly alternative to conventional synthetic ma...