Journal of chemical information and modeling
Nov 6, 2025
Increasing concerns regarding prolonged antibiotic usage have spurred the search for alternative treatments. Antimicrobial peptides (AMPs), first discovered in the 1980s, have exhibited significant potential against a broad range of bacteria. Short-s...
Antimicrobial resistance (AMR) in enterica serotype Kentucky ( Kentucky) is a global challenge, with increasing resistance to cephalosporins, ciprofloxacin, and carbapenems significantly limiting treatment strategies, yet its worldwide dissemination...
Antimicrobial agents and chemotherapy
Oct 31, 2025
While associations of antibiotic resistance traits are not random in multidrug-resistant (MDR) bacteria, clinically relevant resistance patterns remain underexplored. This study used association-set mining to explore resistance associations within i...
Marine biotechnology (New York, N.Y.)
Oct 30, 2025
Antimicrobial resistance is a serious threat to global public health and requires new therapeutic approaches. Antimicrobial peptides (AMP) are recognized as promising candidates to address antimicrobial resistance. AMP can disrupt cell membranes by i...
BACKGROUND: The World Health Organization has identified Stenotrophomonas maltophilia (SM) as a high-risk antibiotic-resistant pathogen. Notably, determining the effectiveness of current antibiotics against SM is challenging, leading to improper ther...
Acta microbiologica et immunologica Hungarica
Oct 21, 2025
Antibiotic-associated diarrhea (AAD) is a prevalent iatrogenic complication of antibiotic therapy, primarily triggered by dysbiosis and loss of intestinal homeostasis. The traditional interventions, such as empirical probiotic use, have shown a modes...
European journal of medicinal chemistry
Oct 16, 2025
Staphylococcus aureus (S. aureus) is one of the most concerned Gram-positive bacteria due to its resistance to the commonly used antibiotics, methicillin. To address the threat of methicillin-resistant S. aureus (MRSA), new classes of antibiotics are...
Deep learning models show promise in accelerating the design and optimization of antimicrobial peptides (AMPs), but current methods face challenges, such as low success rates, or large virtual library scales. In this study, we introduce DLFea4AMPGen,...
OBJECTIVES: Antimicrobial resistance is a critical public health threat. Large language models (LLMs) show great capability for providing health information. This study evaluates the effectiveness of LLMs in providing information on antibiotic use an...
Environmental science. Processes & impacts
Oct 15, 2025
Antibiotics, as emerging contaminants, are increasingly detected in aquatic environments, raising significant concerns about their ecological risks. However, the lack of hydrolysis rate constants () and aqueous hydroxyl radical degradation rate const...
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