AIMC Topic: Anti-Bacterial Agents
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Micro- and Nano-Bots for Infection Control.
Advanced materials (Deerfield Beach, Fla.)
Apr 10, 2025
Medical micro- and nano-bots (MMBs and MNBs) have attracted a lot of attention owing to their precise motion for accessing difficult-to-reach areas in the body. These emerging tools offer the promise of non-invasive diagnostics and therapeutics for a...
Therapeutic effect and concomitant toxicity of hydrargyrum chloratum compositum on chronic difficult-to-heal wounds in rats.
Journal of ethnopharmacology
Apr 10, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: Hydrargyrum chloratum compositum(Hcc) is a traditional Chinese medicine for external use, with the efficacy of 'transforming corrosion and pulling out toxins, removing corrosion and regenerating muscles'. The main comp...
Pre-trained molecular representations enable antimicrobial discovery.
Nature communications
Apr 10, 2025
The rise in antimicrobial resistance poses a worldwide threat, reducing the efficacy of common antibiotics. Determining the antimicrobial activity of new chemical compounds through experimental methods remains time-consuming and costly. While compoun...
Antimicrobial resistance: Linking molecular mechanisms to public health impact.
SLAS discovery : advancing life sciences R & D
Apr 9, 2025
BACKGROUND: Antimicrobial resistance (AMR) develops into a worldwide health emergency through genetic and biochemical adaptations which enable microorganisms to resist antimicrobial treatment. β-lactamases (blaNDM, blaKPC) and efflux pumps (MexAB-Opr...
Febrile neutropenia management in high-risk neutropenic patients: a narrative review on antibiotic prophylaxis and empirical treatment.
Expert review of anti-infective therapy
Apr 4, 2025
INTRODUCTION: Although febrile neutropenia (FN) remains a major cause of morbidity and mortality in patients with hematologic malignancies and hematopoietic stem cell transplant (HSCT) recipients, the increasing prevalence of antimicrobial resistance...
4-Hydroxyboesenbergin B of Alpinia japonica protected gastrointestinal tract by inhibiting vancomycin-resistant enterococcus and balancing intestinal microbiota.
Journal of ethnopharmacology
Apr 1, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: Alpinia japonica, a traditional herb utilized in Miao medicine in southwestern China, has been employed to alleviate symptoms such as stomachache, diarrhea, and abdominal pain, some of these symptoms may be associated ...
Optimizing Initial Vancomycin Dosing in Hospitalized Patients Using Machine Learning Approach for Enhanced Therapeutic Outcomes: Algorithm Development and Validation Study.
Journal of medical Internet research
Mar 31, 2025
BACKGROUND: Vancomycin is commonly dosed using standard weight-based methods before dose adjustments are made through therapeutic drug monitoring (TDM). However, variability in initial dosing can lead to suboptimal therapeutic outcomes. A predictive ...
Machine learning assisted paper-based fluorescent sensor array with metal-doped multicolor carbon quantum dots for identification and inactivation of bacteria.
Talanta
Mar 27, 2025
Bacterial infection is a thorny threat in a variety of fields, including medicine, environment, food, and agriculture. A multifunctional platform that meets the demands of both bacterial identification and real-time inactivation is urgently needed. T...
Machine learning-based prediction of vesicoureteral reflux outcomes in infants under antibiotic prophylaxis.
Scientific reports
Mar 22, 2025
We aimed to investigate the independent outcome predictors of continuous antibiotic prophylaxis (CAP) in vesicoureteral reflux, train a model to predict the outcome, and evaluate which infants should be referred for endoscopic vesicoureteral reflux c...
Assessment for antibiotic resistance in : A practical and interpretable machine learning model based on genome-wide genetic variation.
Virulence
Mar 21, 2025
() antibiotic resistance poses a global health threat. Accurate identification of antibiotic resistant strains is essential for the control of infection. In the present study, our goal is to leverage the whole-genome data of to develop practical an...
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