AIMC Topic: Anti-Infective Agents
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Recurrent Neural Network Model for Constructive Peptide Design.
Journal of chemical information and modeling
Jan 22, 2018
We present a generative long short-term memory (LSTM) recurrent neural network (RNN) for combinatorial de novo peptide design. RNN models capture patterns in sequential data and generate new data instances from the learned context. Amino acid sequenc...
Effect of nano-silver, nano-copper, deconex and benzalkonium chloride on biofilm formation and expression of transcription regulatory quorum sensing gene (rh1R) in drug-resistance Pseudomonas aeruginosa burn isolates.
Burns : journal of the International Society for Burn Injuries
Dec 28, 2017
BACKGROUND: Biofilm forming drug-resistant Pseudomonas aeruginosa are responsible for major death in burn center of different hospitals across the globe.
Supervised learning for infection risk inference using pathology data.
BMC medical informatics and decision making
Dec 8, 2017
BACKGROUND: Antimicrobial Resistance is threatening our ability to treat common infectious diseases and overuse of antimicrobials to treat human infections in hospitals is accelerating this process. Clinical Decision Support Systems (CDSSs) have been...
Innovative material containing the natural product curcumin, with enhanced antimicrobial properties for active packaging.
Materials science & engineering. C, Materials for biological applications
Nov 28, 2017
Curcumin (Curc) reacts with zinc di‑iodine (ZnI) in 2:1molar ratio in the presence of an excess of a base triethylamine ((CHCH)N) in methanol (CHOH) solution towards the amorphous solid material of formula [ZnI(Curc)] (1). The complex was characteriz...
Universal simultaneous multiplex ELISA of small molecules in milk based on dual luciferases.
Analytica chimica acta
Nov 22, 2017
The enzyme-linked immunosorbent assay (ELISA) has become the most important and widely used rapid detection technology for food safety because of its simple operation, fast speed and high sensitivity. Multiplex synchronous detection is the goal of EL...
Desert actinobacteria as a source of bioactive compounds production with a special emphases on Pyridine-2,5-diacetamide a new pyridine alkaloid produced by Streptomyces sp. DA3-7.
Microbiological research
Nov 21, 2017
In the present study, 134 morphologically distinct actinobacteria isolates were obtained from soil samples from 10 different localities in the Saudi Arabian desert. The preliminary screening revealed that 16 of these isolates possessed antimicrobial ...
Pyridines
MCF-7 Cells
Enterococcus faecalis
Alkaloids
Cryptococcus neoformans
Desert Climate
Escherichia coli
Breast Neoplasms
Streptomyces
Humans
Antineoplastic Agents
Microbial Sensitivity Tests
Soil Microbiology
Anti-Infective Agents
Saudi Arabia
Salmonella typhimurium
Female
Cell Line, Tumor
Adenocarcinoma
Monitoring of antimicrobial susceptibility of udder pathogens recovered from cases of clinical mastitis in dairy cows across Europe: VetPath results.
Veterinary microbiology
Nov 21, 2017
VetPath is an ongoing pan-European antimicrobial susceptibility monitoring programme collecting pathogens from diseased cattle, pigs and poultry not recently treated with antibiotics. Non-duplicate milk samples were collected from cows with acute cli...
Ultrasound-assisted extraction of antimicrobial compounds from Thymus daenensis and Silybum marianum: Antimicrobial activity with and without the presence of natural silver nanoparticles.
Ultrasonics sonochemistry
Nov 2, 2017
The present study is devoted to prepare a new antibacterial and antifungal agent based on in situ-synthesized silver nanoparticles at room temperature using Rosmarinus officinalis (R. officinalis) leaf extract. The Ag-NPs characterization by UV-visib...
Machine learning-enabled discovery and design of membrane-active peptides.
Bioorganic & medicinal chemistry
Jul 8, 2017
Antimicrobial peptides are a class of membrane-active peptides that form a critical component of innate host immunity and possess a diversity of sequence and structure. Machine learning approaches have been profitably employed to efficiently screen s...
Synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents.
Bioorganic & medicinal chemistry letters
Dec 29, 2016
Microbial resistance to antibiotics is a global concern. The World Health Organization (WHO) has identified antimicrobial resistance as one the three greatest threats for human beings in the 21st century. Without urgent and coordinated action, the wo...
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