Protein science : a publication of the Protein Society
Sep 1, 2025
Mesothelin (MSLN) is a cell surface glycoprotein overexpressed in many solid tumors, which is known to interact with cancer antigen CA125/MUC16, promoting cancer cell adhesion and metastasis. MSLN has been used as a target of multiple antibody-based ...
UNLABELLED: A subset of cancers present with unclear or potentially incorrect primary histopathologic diagnoses, including cancers of unknown primary (CUP). We aimed to develop and validate an artificial intelligence (AI) tool, Genomic Probability Sc...
BACKGROUND: Considerable evidence highlights the intricate association between liquid-liquid phase separation (LLPS) and tumorigenesis, progression, and therapy resistance. However, there has been limited exploration of the role of LLPS in hepatoblas...
The identification of key features and reliable phenotype classification remains pivotal in cancer research, with direct implications for early diagnosis, prognosis, treatment optimization, and cost reduction in healthcare. This study introduces a hy...
BACKGROUND: Multiple myeloma (MM) is a hematological malignancy that progresses from a benign precursor stage known as Monoclonal Gammopathy of Undetermined Significance (MGUS). Distinguishing MM from MGUS at the molecular level by identifying key bi...
Predicting drug responses using genetic and transcriptomic features is crucial for enhancing personalized medicine. In this study, we implemented an ensemble of machine learning algorithms to analyze the correlation between genetic and transcriptomic...
PURPOSE OF REVIEW: Lymphangioleiomyomatosis (LAM) is a systemic, low-grade, metastasizing neoplasm that predominantly affects women. This review demonstrates recent progression in this rare disease, from improved understanding of pathogenesis, to nov...
Critical reviews in oncology/hematology
Sep 1, 2025
Over the past decade, liquid biopsy (LB) has emerged as a key tool in oncology. Its utility in non-invasive sampling and real-time monitoring has made it a cornerstone in precision medicine. Since 2020, publications on LB in solid tumors have doubled...
Critical reviews in oncology/hematology
Sep 1, 2025
INTRODUCTION: Breast cancer is the most prevalent cancer among women, with growing incidence and mortality rates. Regardless of remarkable progress in cancer research, breast cancer remains a major concern due to its complex nature. These factors und...
PURPOSE OF REVIEW: Biochemical recurrence (BCR) after radical prostatectomy exhibits heterogeneous prognostic implications. Recent advancements in imaging and biomarkers have high potential for personalizing care.
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