AIMC Topic: Biomarkers

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Machine Learning Feasibility in Cochlear Implant Speech Perception Outcomes-Moving Beyond Single Biomarkers for Cochlear Implant Performance Prediction.

Ear and hearing
OBJECTIVES: Machine learning (ML) is an emerging discipline centered around complex pattern matching and large data-based prediction modeling and can improve precision medicine healthcare. Cochlear implants (CI) are highly effective, however, outcome...

DUAL VALIDATION ANALYSIS OF SERUM CYP3A4 IN PREDICTING NEC IN PRETERM INFANTS.

Shock (Augusta, Ga.)
Objective: Necrotizing enterocolitis (NEC) is a life-threatening condition in premature infants, where timely diagnosis and intervention are crucial. This study investigated the potential of serum CYP3A4 as an early predictive biomarker for NEC and d...

A quantum inspired machine learning approach for multimodal Parkinson's disease screening.

Scientific reports
Parkinson's disease, currently the fastest-growing neurodegenerative disorder globally, has seen a 50% increase in cases within just two years. As disease progression impairs speech, memory, and motor functions over time, early diagnosis is crucial f...

Machine learning based association between inflammation indicators (NLR, PLR, NPAR, SII, SIRI, and AISI) and all-cause mortality in arthritis patients with hypertension: NHANES 1999-2018.

Frontiers in public health
BACKGROUND: This study aimed to evaluate the relationship between CBC-derived inflammatory markers (NLR, PLR, NPAR, SII, SIRI, and AISI) and all-cause mortality (ACM) risk in arthritis (AR) patients with hypertensive (HTN) using data from the NHANES.

Identification of Crohn's Disease-Related Biomarkers and Pan-Cancer Analysis Based on Machine Learning.

Mediators of inflammation
: In recent years, the incidence of Crohn's disease (CD) has shown a significant global increase, with numerous studies demonstrating its correlation with various cancers. This study aims to identify novel biomarkers for diagnosing CD and explore the...

Can small dense LDL cholesterol be estimated from the lipid profile?

Current opinion in lipidology
PURPOSE OF REVIEW: Small dense low-density lipoprotein cholesterol (sdLDL-C) is recognized for its strong atherosclerogenic potential. However, its direct measurement remains impractical in clinical settings due to its high cost, time constraints, an...

Urinary biomarkers of kidney transplant rejection.

Current opinion in organ transplantation
PURPOSE OF REVIEW: Despite the introduction of many new immunosuppressive medications, allograft rejection remains a significant complication in transplantation. The use of "liquid biopsy" to evaluate allograft function and detect early rejection has...

Improved prediction and risk stratification of major adverse cardiovascular events using an explainable machine learning approach combining plasma biomarkers and traditional risk factors.

Cardiovascular diabetology
BACKGROUND: Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality globally. Traditional risk models, primarily based on established risk factors, often lack the precision needed to accurately predict new-onset major advers...

Identification of novel IL17-related genes as prognostic and therapeutic biomarkers of psoriasis using comprehensive bioinformatics analysis and machine learning.

Scientific reports
Psoriasis is a common chronic skin disorder with a polygenic background. It is widely acknowledged that Th17/IL-17A axis plays a key role in the pathogenesis of psoriasis. However, numerous regulatory genes upstream of the pathway remain undiscovered...

Identification of biomarkers associated with M1 macrophages in the ST-segment elevation myocardial infarction through bioinformatics and machine learning approaches.

Scientific reports
ST-segment elevation myocardial infarction (STEMI) is considered a critical cardiac condition with a poor prognosis. Shortly after STEMI occurs, the increased number of circulating leukocytes including macrophages can lead to the accumulation of more...