AIMC Topic: Case-Control Studies

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cfDNAFE: Comprehensively extracting multi-omics features of cell-free DNA for noninvasive diagnosis.

Methods (San Diego, Calif.)
The tissues-of-origin of circulating cell-free DNA (cfDNA) holds great promise for non-invasive diagnosing cancers, monitoring allograft rejection, and prenatal testing. Many features for inferring the tissues-of-origin of cfDNAs are being revealed f...

Machine learning for classification of pediatric bipolar disorder with and without psychotic symptoms based on thalamic subregional structural volume.

BMC psychiatry
BACKGROUND: The thalamus plays a crucial role in sensory processing, emotional regulation, and cognitive functions, and its dysregulation may be implicated in psychosis. The aim of the present study was to examine the differences in thalamic subregio...

Comparison of salivary statherin and beta-defensin-2 levels, oral health behaviors, and demographic factors in children with and without early childhood caries.

BMC oral health
BACKGROUND: Early childhood caries (ECC) is a widespread pediatric dental condition that is influenced by a combination of biological, behavioral, and demographic factors. Salivary biomarkers, including beta-defensin-2 (BD-2) and statherin (STATH), o...

TRAF3 as a potential diagnostic biomarker for recurrent pregnancy loss: insights from single-cell transcriptomics and machine learning.

BMC pregnancy and childbirth
BACKGROUND: Recurrent pregnancy loss (RPL), characterized by multiple miscarriages, remains a condition with unclear etiology, posing significant challenges for affected women and couples. This study aims to explore the underlying mechanisms of RPL, ...

Contrastive functional connectivity defines neurophysiology-informed symptom dimensions in major depression.

Cell reports. Medicine
Major depressive disorder (MDD) is highly heterogeneous, posing challenges for effective treatment due to complex interactions between clinical symptoms and neurobiological features. To address this, we apply contrastive principal-component analysis ...

C2 pars interarticularis length on the side of high-riding vertebral artery with implications for pars screw insertion.

Scientific reports
C2 pars interarticularis length (C2PIL) required for pars screws has not been thoroughly studied in subjects with high-riding vertebral artery (HRVA). We aimed to measure C2PIL specifically on the sides with HRVA, define short pars, optimal pars scre...

Task-specific differentiation of patellofemoral pain in women using a neural network analysis of joint angle subsets.

Gait & posture
BACKGROUND: Individuals with patellofemoral pain (PFP) present mechanical disorders during functional tests and activities. Studies often evaluate this population to understand the relationship between mechanical factors and pain/malalignment. This s...

Exploring voice as a digital phenotype in adults with ADHD.

Scientific reports
Current diagnostic procedures for attention deficit hyperactivity disorder (ADHD) are mainly subjective and prone to bias. While research on potential biomarkers, including EEG, brain imaging, and genetics is promising, it has yet to demonstrate clin...

The Gut Microbiota in Young Adults with High-Functioning Autism Spectrum Disorder and Its Performance as Diagnostic Biomarkers.

Nutrients
Diagnosing ASD in adults presents unique challenges, and there are currently no specific biomarkers for this condition. Most existing studies on the gut microbiota in ASD are conducted in children; however, the composition of the gut microbiota in c...

Identification of a panel of volatile organic compounds in urine for early detection of for bladder cancer.

Scientific reports
The absence of specific markers makes early detection of bladder cancer (BC) challenging. Recent studies have reported the reliable diagnostic significance of volatile organic compounds (VOCs) in several cancers. This study aimed to investigate wheth...