AIMC Topic: Cell-Free Nucleic Acids

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Deep centroid: a general deep cascade classifier for biomedical omics data classification.

Bioinformatics (Oxford, England) Feb 1, 2024
MOTIVATION: Classification of samples using biomedical omics data is a widely used method in biomedical research. However, these datasets often possess challenging characteristics, including high dimensionality, limited sample sizes, and inherent bia...
DNA Methylation Cell-Free Nucleic Acids Early Detection of Cancer Humans Neoplasms Machine Learning Transcriptome Precision Medicine
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Unlocking Early Cancer Detection: Leveraging Machine Learning in Cell-Free DNA Analysis for Precision Oncology.

AMIA ... Annual Symposium proceedings. AMIA Symposium Jan 1, 2024
This study introduces a groundbreaking approach to early cancer detection through the analysis of cell-free DNA (cfDNA), utilizing machine learning algorithms to navigate the complexities of low circulating tumor DNA (ctDNA) fractions and genetic het...
Humans Machine Learning Algorithms Cell-Free Nucleic Acids Precision Medicine High-Throughput Nucleotide Sequencing Biomarkers, Tumor Early Detection of Cancer Circulating Tumor DNA Neoplasms
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Identify gestational diabetes mellitus by deep learning model from cell-free DNA at the early gestation stage.

Briefings in bioinformatics Nov 22, 2023
Gestational diabetes mellitus (GDM) is a common complication of pregnancy, which has significant adverse effects on both the mother and fetus. The incidence of GDM is increasing globally, and early diagnosis is critical for timely treatment and reduc...
Humans Diabetes, Gestational beta-Defensins Pregnancy Female Pregnancy Outcome Deep Learning Cell-Free Nucleic Acids DNA Copy Number Variations
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DISMIR: Deep learning-based noninvasive cancer detection by integrating DNA sequence and methylation information of individual cell-free DNA reads.

Briefings in bioinformatics Nov 5, 2021
Detecting cancer signals in cell-free DNA (cfDNA) high-throughput sequencing data is emerging as a novel noninvasive cancer detection method. Due to the high cost of sequencing, it is crucial to make robust and precise predictions with low-depth cfDN...
DNA Methylation Cell-Free Nucleic Acids Early Detection of Cancer Deep Learning Computational Biology Sequence Analysis, DNA DNA, Neoplasm Organ Specificity Nucleotide Motifs Neoplasm Staging High-Throughput Nucleotide Sequencing Liquid Biopsy Humans Neoplasms
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Tri-modal liquid biopsy: Combinational analysis of circulating tumor cells, exosomes, and cell-free DNA using machine learning algorithm.

Clinical and translational medicine Aug 1, 2021
Neoplastic Cells, Circulating Exosomes Survival Analysis Liquid Biopsy Circulating Tumor DNA Humans Machine Learning Cell-Free Nucleic Acids
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Liver and Lung Transplant Advances.

JAMA Mar 12, 2019
Lung Transplantation Waiting Lists End Stage Liver Disease Male Machine Learning Lung Diseases Severity of Illness Index Prognosis Liver Transplantation Cell-Free Nucleic Acids Humans Delayed Graft Function Female Graft Rejection
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miRandola 2017: a curated knowledge base of non-invasive biomarkers.

Nucleic acids research Jan 4, 2018
miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance of ncRNAs as non-invasive biomarkers. An increasing amount of experimental evidence shows ...
Databases, Genetic Cell-Free Nucleic Acids MicroRNAs RNA Data Curation Humans RNA, Long Noncoding RNA, Untranslated Biomarkers RNA, Circular Knowledge Bases User-Computer Interface
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Cell Free DNA and Procalcitonin as Early Markers of Complications in ICU Patients with Multiple Trauma and Major Surgery.

Clinical laboratory Dec 1, 2016
BACKGROUND: Cell free DNA (cfDNA) was recently suggested as a new marker of sepsis and poor outcome in ICU patients. Procalcitonin has also been the focus of attention as an early marker for systemic inflammation and sepsis.
Injury Severity Score ROC Curve Risk Factors Organ Dysfunction Scores Cell-Free Nucleic Acids Adult Calcitonin Multiple Trauma Male DNA Sepsis Predictive Value of Tests Middle Aged Early Diagnosis Postoperative Complications Time Factors C-Reactive Protein Surgical Procedures, Operative Humans Intensive Care Units Length of Stay Hospital Mortality Lactic Acid Area Under Curve Biomarkers Female Prognosis Reproducibility of Results
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